Expression of bcl-2 in invasive and in situ carcinoma of the uterine cervix

OBJECTIVE: The oncoprotein bcl-2 inhibits apoptosis. The purpose of this study was to assess the expression of bcl-2 in human cervical carcinoma and to correlate this with clinicopathologic parameters. STUDY DESIGN: Immunohistochemical staining for bcl-2 protein (MoAB clone 124) was performed on ope...

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Veröffentlicht in:	American journal of obstetrics and gynecology 1998, Vol.178 (1), p.113-117
Hauptverfasser:	Tjalma, Wiebren, De Cuyper d, Eva, Weyler, Joost, Van Marck, Eric, De Pooter, Christel, Albertyn, Georges, van Dam, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Apoptosis bcl-2 Biological and medical sciences Carcinoma in Situ - chemistry Carcinoma in Situ - genetics Carcinoma in Situ - pathology cervical carcinoma Female Female genital diseases Gene Expression Regulation, Neoplastic Genes, bcl-2 - genetics Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Life Tables Medical sciences Middle Aged Multivariate Analysis Neoplasm Invasiveness Neoplasm Staging oncoprotein Prognosis Proportional Hazards Models Proto-Oncogene Proteins c-bcl-2 - analysis Proto-Oncogene Proteins c-bcl-2 - genetics Tumors Uterine Cervical Neoplasms - chemistry Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology
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Beschreibung
Zusammenfassung:	OBJECTIVE: The oncoprotein bcl-2 inhibits apoptosis. The purpose of this study was to assess the expression of bcl-2 in human cervical carcinoma and to correlate this with clinicopathologic parameters. STUDY DESIGN: Immunohistochemical staining for bcl-2 protein (MoAB clone 124) was performed on operative tissue specimens from 22 patients with carcinoma in situ of the cervix and from 137 patients with invasive cervical carcinoma (International Federation of Gynecology and Obstetrics stages I to IV). The immunoreactivity of bcl-2 was scored as positive (≥5% staining cells) or negative (
ISSN:	0002-9378 1097-6868
DOI:	10.1016/S0002-9378(98)70636-2