Familial macrothrombocytopenia associated with decreased glycosylation of platelet membrane glycoprotein IV

A case of hereditary thrombocytopenia with large platelets (familial macrothrombocytopenia, FM) is reported. Studies on the platelets from the propositus showed decreased glycosylation of platelet membrane glycoprotein IV, which would distinguish the case from other FM previously described.

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Bibliographische Detailangaben
Veröffentlicht in:	American journal of hematology 1990-04, Vol.33 (4), p.271-273
Hauptverfasser:	Yufu, Yuji, Ideguchi, Hiroshi, Narishige, Takahiro, Suematsu, Eiichi, Toyoda, Kazunori, Nishimura, Junji, Nawata, Hajime, Oda, Susumu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromosome Aberrations - blood Chromosome Disorders Family Health glycoprotein IV Glycosylation Hematologic and hematopoietic diseases hereditary thrombocytopenia Humans large platelet Male Medical sciences Middle Aged Platelet diseases and coagulopathies Platelet Membrane Glycoproteins - metabolism platelet surface protein platelets Thrombocytopenia - genetics
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Beschreibung
Zusammenfassung:	A case of hereditary thrombocytopenia with large platelets (familial macrothrombocytopenia, FM) is reported. Studies on the platelets from the propositus showed decreased glycosylation of platelet membrane glycoprotein IV, which would distinguish the case from other FM previously described.
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.2830330411