Localized amyloidosis of the parotid gland: A case report and review of the localized amyloidosis of the head and neck

Background Localized amyloidosis in the head and neck is a rare and benign process. Methods We present the first case report in the literature of localized amyloidosis of the parotid glands and also comprehensively review the literature regarding localized amyloidosis of the head and neck. Results Amyloidosis affecting the head and neck region is uncommon and is mostly in the form of localized amyloidosis. Larynx is the commonest site of involvement and accounts for 0.2% to 0.5% of benign laryngeal tumors. Laryngeal involvement could be either diffuse subepithelial deposition or discrete tumor nodules. Although localized amyloidosis occurs much more frequently in the oral cavity and pharynx, only seven cases of nasopharyngeal amyloidosis and eight cases of nasal septum amyloidosis have been reported. There is no documentation to suggest that localized amyloidosis can progress to systemic amyloidosis. Local surgical excision is the treatment of choice for laryngeal amyloidosis and laser excision is probably the best. Conclusion While localized amyloidosis of the head and neck region is rare, it should be recognized, understood, evaluated, and properly treated. © 1998 John Wiley & Sons, Inc. Head Neck 20: 73–78, 1998.