Resveratrol, a remarkable inhibitor of ribonucleotide reductase

Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further...

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Veröffentlicht in:	FEBS letters 1998-01, Vol.421 (3), p.277-279
Hauptverfasser:	Fontecave, Marc, Lepoivre, Michel, Elleingand, Eric, Gerez, Catherine, Guittet, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer agent DNA, Neoplasm Enzyme Inhibitors - pharmacology Free Radicals Humans Mice Nucleic Acid Synthesis Inhibitors - pharmacology Recombinant Fusion Proteins - antagonists & inhibitors Recombinant Fusion Proteins - genetics Resveratrol Ribonucleotide reductase Ribonucleotide Reductases - antagonists & inhibitors Ribonucleotide Reductases - genetics Stilbenes - pharmacology Tumor Cells, Cultured Tyrosine - metabolism Tyrosyl radical
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Beschreibung
Zusammenfassung:	Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/S0014-5793(97)01572-X