Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria

Kun et al determine the frequency of sickle-cell trait, and found a significant difference, in the same range as the distribution of the nitric oxide-synthase 2 (NOS2) promoter mutation. Data suggest that a new NOS2 promoter mutation is restricted to an area that is highly endemic for malaria.

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Bibliographische Detailangaben
Veröffentlicht in:	The Lancet (British edition) 1998-01, Vol.351 (9098), p.265-266
Hauptverfasser:	Kun, Jürgen FJ, Mordmüller, Benjamin, Lell, Bertrand, Lehman, Leopold G, Luckner, Doris, Kremsner, Peter G
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Case-Control Studies Child, Preschool Female Gabon Genetics Human protozoal diseases Humans Infectious diseases Malaria Malaria, Falciparum - genetics Male Medical sciences Mutation Nitric oxide Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Nitrogen Parasitic diseases Point Mutation Polymorphism, Genetic Promoter Regions, Genetic - genetics Protozoal diseases Severity of Illness Index Sickle cell anemia Tropical medicine Vector-borne diseases
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Beschreibung
Zusammenfassung:	Kun et al determine the frequency of sickle-cell trait, and found a significant difference, in the same range as the distribution of the nitric oxide-synthase 2 (NOS2) promoter mutation. Data suggest that a new NOS2 promoter mutation is restricted to an area that is highly endemic for malaria.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(05)78273-8