Anti-PreS2 antibody assay for evaluating immune responses among recipients of recombinant hepatitis B PreS2+S vaccine

A competitive radioimmunoassay was developed for measuring hepatitis B virus (HBV) anti‐PreS2 antibody. The assay has been demonstrated to be highly specific for anti‐PreS2 antibody and not subject to interference by other antibodies to HBV‐specific antigens. This assay was used to evaluate anti‐Pre...

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Veröffentlicht in:	Journal of medical virology 1990-02, Vol.30 (2), p.146-150
Hauptverfasser:	Hurni, William M., Roehm, Robert R., Miller, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Antibodies, Viral - analysis Biological and medical sciences clinical trial competitiveria Evaluation Studies as Topic Fundamental and applied biological sciences. Psychology HBV Hepatitis Antibodies - analysis Hepatitis B - immunology Hepatitis B Surface Antigens - immunology Hepatitis B virus - immunology Humans MAb Microbiology Protein Precursors - immunology Radioimmunoassay - methods Vaccines - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - immunology Virology
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Beschreibung
Zusammenfassung:	A competitive radioimmunoassay was developed for measuring hepatitis B virus (HBV) anti‐PreS2 antibody. The assay has been demonstrated to be highly specific for anti‐PreS2 antibody and not subject to interference by other antibodies to HBV‐specific antigens. This assay was used to evaluate anti‐PreS2 antibody responses in a hepatitis B PreS2+S vaccine human clinical trial in healthy adults.
ISSN:	0146-6615 1096-9071
DOI:	10.1002/jmv.1890300213