Hematoporphyrin derivatives: An oligomeric composition study

Hematoporphyrin derivatives: An oligomeric composition study

The oligomeric composition of HpD, Photofrin II and other hematoporphyrin derivatives useful for the diagnosis and therapy of tumors has been studied. Gel chromatographic procedures were used that excluded porphyrin aggregation. Photofrin and hematoporphyrin derivatives were shown to contain differe...

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Veröffentlicht in:Journal of photochemistry and photobiology. B, Biology Biology, 1990, Vol.4 (3), p.297-306
Hauptverfasser: Mironov, Andrei F., Nizhnik, Alexander N., Nockel, Alexei Yu
Format: Artikel
Sprache:eng
Schlagworte:
aggregation
Analytical, structural and metabolic biochemistry
Biological and medical sciences
cancer phototherapy
Chromatography, Gel
Chromatography, Thin Layer
dihematoporphyrin ether
Drug Stability
Fundamental and applied biological sciences. Psychology
gel chromatography
hematoporphyrin derivatives
Hematoporphyrins - analysis
Hemoproteins
Metalloproteins
photosensitization
Polymers
Porphyrins
Proteins
Solutions
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Zusammenfassung:The oligomeric composition of HpD, Photofrin II and other hematoporphyrin derivatives useful for the diagnosis and therapy of tumors has been studied. Gel chromatographic procedures were used that excluded porphyrin aggregation. Photofrin and hematoporphyrin derivatives were shown to contain different quantities of monomer, dimer and other oligomeric porphyrins.
ISSN:1011-1344
1873-2682
DOI:10.1016/1011-1344(90)85035-U