The sarcolemmal Ca2+-ATPase of the ischemic-reperfused myocardium: protective effect of hypocalcemia on calmodulin-stimulated activity

This study was designed to examine the role of calcium in the ischemia-induced changes of calmodulin-stimulated Ca2+-ATPase activity of heart sarcolemma of dogs subjected to coronary artery ligation (90 min) and reperfusion (30 min). This was attained by the application of systemic hemodialysis with...

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Veröffentlicht in:	Life sciences (1973) 1998, Vol.62 (1), p.29-36
Hauptverfasser:	Samouilidou, E C, Karli, J N, Levis, G M, Darsinos, J T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Transporting ATPases - drug effects Calcium-Transporting ATPases - metabolism Calmodulin - metabolism Calmodulin - pharmacology Dogs Female Heart - drug effects Hypocalcemia - physiopathology Male Myocardial Ischemia - metabolism Myocardial Reperfusion Myocardium - enzymology Sarcolemma - drug effects Sarcolemma - enzymology
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Zusammenfassung:	This study was designed to examine the role of calcium in the ischemia-induced changes of calmodulin-stimulated Ca2+-ATPase activity of heart sarcolemma of dogs subjected to coronary artery ligation (90 min) and reperfusion (30 min). This was attained by the application of systemic hemodialysis with low Ca2+ dialysate in six dogs (group A) and the comparison of the results with those obtained from animals subjected to normal Ca2+ hemodialysis (control group B, n=7). A very significant (p
ISSN:	0024-3205