A new classification for HIV-1

The phenotype of HIV-1 isolates is defined by the cells in which they replicate in vitro , but these phenotypes can change in vivo with profound implications for viral transmission, pathogenesis and disease progression. Here we propose a new classification system based on co-receptor use, providing...

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Veröffentlicht in:	Nature (London) 1998-01, Vol.391 (6664), p.240-240
Hauptverfasser:	Berger, E. A., Doms, R. W., Fenyö, E.-M., Korber, B. T. M., Littman, D. R., Moore, J. P., Sattentau, Q. J., Schuitemaker, H., Sodroski, J., Weiss, R. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS AIDS/HIV Classification Disease transmission HIV Infections - transmission HIV Infections - virology HIV-1 - classification HIV-1 - metabolism Human immunodeficiency virus 1 Humanities and Social Sciences Humans Laboratories Medical research multidisciplinary Receptors, CCR5 - metabolism Receptors, CXCR4 - metabolism Science Science (multidisciplinary) scientific-correspondence Viruses
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Beschreibung
Zusammenfassung:	The phenotype of HIV-1 isolates is defined by the cells in which they replicate in vitro , but these phenotypes can change in vivo with profound implications for viral transmission, pathogenesis and disease progression. Here we propose a new classification system based on co-receptor use, providing a more accurate description of viral phenotype than the present imprecise and often misleading classification schemes.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/34571