The frequency of mouse spleen dendritic cells which present alloantigens or ovalbumin to primed T lymphocytes is equal

We have used limiting dilution analysis to compare the frequency of dendritic cells (DC) which present endogenous alloantigens with that which present an exogenous protein antigen to T lymphocytes. Spleen DC present alloantigens or ovalbumin to primed T lymphocytes with equal frequency, showing that...

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Veröffentlicht in:	Cellular immunology 1990-04, Vol.126 (2), p.406-413
Hauptverfasser:	Goodacre, John A., Johnstone, Robin, Atherton, Marian C., Robinson, John H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Antigen-Presenting Cells - immunology Biological and medical sciences Cell interactions Dendritic Cells - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Histocompatibility Antigens Class II - analysis Immunobiology Isoantigens - immunology Lymphocyte Culture Test, Mixed Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Ovalbumin - immunology Spleen - immunology T-Lymphocytes - immunology
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Zusammenfassung:	We have used limiting dilution analysis to compare the frequency of dendritic cells (DC) which present endogenous alloantigens with that which present an exogenous protein antigen to T lymphocytes. Spleen DC present alloantigens or ovalbumin to primed T lymphocytes with equal frequency, showing that DC are equipotent for presenting endogenous and exogenous antigens. Also, antigen-presenting cell (APC) frequencies among DC were compared with other APC populations. DC were enriched about 1000-fold for APC compared to unfractionated spleen cells.
ISSN:	0008-8749 1090-2163
DOI:	10.1016/0008-8749(90)90331-K