Structure of human pancreatic lipase

PANCREATIC lipase (triacylglycerol acyl hydrolase) fulfills a key function in dietary fat absorption by hydrolysing triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids. We have determined the three-dimensional structure of the human enzyme, a single-chain glycop...

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Veröffentlicht in:	Nature (London) 1990-02, Vol.343 (6260), p.771-774
Hauptverfasser:	Winkler, F. K, D'Arcy, A, Hunziker, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Analytical, structural and metabolic biochemistry Anatomy & physiology Base Sequence Binding Sites Biochemistry Biological and medical sciences Catalysis Chemical bonds Crystallography Deoxyribonucleic acid Diet & nutrition Diglycerides DNA Electron density Enzymatic activity Enzymes Enzymes and enzyme inhibitors Fatty acids Fundamental and applied biological sciences. Psychology Homology Humanities and Social Sciences Humans Hydrogen Hydrogen bonds Hydrolase Hydrolases Hydroxyl groups Interfaces letter Lipase Lipase - genetics Lipids man Medical research Molecular Sequence Data Molecular Structure Monoglycerides multidisciplinary Pancreas Pancreas - enzymology Protein Conformation Proteins Science Science (multidisciplinary) Serine Solvents Substrates Superposition (mathematics) Triglycerides X-Ray Diffraction
Online-Zugang:	Volltext
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