Desulfuration of the insecticide parathion by human placenta in vitro

Desulfuration of the insecticide parathion by human placenta in vitro

The present study, by quantifying covalently bound ( super(35)S) after incubation of placental homogenates with ( super(35)S)parathion (O,O-diethyl-O-(4-nitrophenyl)-phosphorothioate), demonstrates the capacity of human placentae from nonsmokers to desulfurate this organothiophosphate insecticide.

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Bibliographische Detailangaben
Veröffentlicht in:Biochemical pharmacology 1990-02, Vol.39 (4), p.799-801
Hauptverfasser: Sultatos, Lester G., Gagliardi, Carol L.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Cytochrome P-450 Enzyme System - metabolism
Female
Humans
Medical sciences
NADP - metabolism
Parathion - metabolism
Pesticides, fertilizers and other agrochemicals toxicology
Placenta - enzymology
Pregnancy
Sulfur - metabolism
Toxicology
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Zusammenfassung:The present study, by quantifying covalently bound ( super(35)S) after incubation of placental homogenates with ( super(35)S)parathion (O,O-diethyl-O-(4-nitrophenyl)-phosphorothioate), demonstrates the capacity of human placentae from nonsmokers to desulfurate this organothiophosphate insecticide.
ISSN:0006-2952
1873-2968
DOI:10.1016/0006-2952(90)90163-F