INTRACYTOPLASMIC NEURONAL INCLUSIONS IN WOODCHUCK BRAIN STEM

Homogenous eosinophilic intracytoplasmic inclusion bodies were found within the large reticular neurons of the brain stems of 57 captive woodchucks (Marmota monax). Light microscopy was consistent with a proteinaceous nature, while electron microscopy suggested a non-viral origin. The woodchucks wit...

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Veröffentlicht in:	Journal of wildlife diseases 1990-01, Vol.26 (1), p.62-66
Hauptverfasser:	Pierce, Virginia, Snyder, Robert L., McGrath, John T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - pathology Animals brain stem Brain Stem - ultrastructure captive study Female Inclusion Bodies - ultrastructure Male Marmota - anatomy & histology Marmota monax Microscopy, Electron neuronal inclusion bodies Neurons - ultrastructure nonspecific ageing changes prevalence Sciuridae - anatomy & histology woodchuck
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Zusammenfassung:	Homogenous eosinophilic intracytoplasmic inclusion bodies were found within the large reticular neurons of the brain stems of 57 captive woodchucks (Marmota monax). Light microscopy was consistent with a proteinaceous nature, while electron microscopy suggested a non-viral origin. The woodchucks with inclusions were older than the general population that was studied. It is hypothesized that the neuronal inclusions in the brain stem are indicative of nonspecific ageing changes.
ISSN:	0090-3558 1943-3700
DOI:	10.7589/0090-3558-26.1.62