Effects of methotrexate on early pregnancy in mice

Single s.c. injection of MTX at dosages of 8, 24 and 72 mg.kg-1 on day 7 of gestation was found to have a feticide effect in mice. The mortality of fetuses on day 13 of pregnancy was 18.0%, 55.5% and 60.3%, respectively. Treatment with MTX caused a decrease of serum progesterone level on day 13 of p...

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Veröffentlicht in:	Yao hsüeh hsüeh pao 1998, Vol.33 (1), p.10-13
Hauptverfasser:	Wang, N, Guan, M, Zheng, W
Format:	Artikel
Sprache:	chi
Schlagworte:	Abortifacient Agents, Nonsteroidal - pharmacology Abortifacient Agents, Steroidal - pharmacology Animals Female Folic Acid Antagonists - pharmacology Male Methotrexate - pharmacology Mice Mice, Inbred ICR Mifepristone - pharmacology Pregnancy Pregnancy, Animal - drug effects
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Zusammenfassung:	Single s.c. injection of MTX at dosages of 8, 24 and 72 mg.kg-1 on day 7 of gestation was found to have a feticide effect in mice. The mortality of fetuses on day 13 of pregnancy was 18.0%, 55.5% and 60.3%, respectively. Treatment with MTX caused a decrease of serum progesterone level on day 13 of pregnancy. Treatment with MTX at a dosage of 24 mg.kg-1 on day 7-9 of gestation terminated total early pregnancy. MTX combined with hCG 10 U/mouse or progesterone 0.2 mg/mouse was shown to have antagonistic effect to terminate early pregnancy. Synergism of RU486 combined with MTX on termination of early pregnancy in mice was observed.
ISSN:	0513-4870