ADPase activity in human maternal and cord blood: possible evidence for a placenta-specific vascular protective mechanism

ADPase enzyme activity was assessed in maternal and cord plasma by adding radio-labelled ADP and quantitating the degradation products. Cord plasma had sufficiently greater ADPase activity than the corresponding maternal plasma obtained ante- and post-partum. Thus, residual radiolabelled ADP was 30,...

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Veröffentlicht in:	International journal of gynecology and obstetrics 1990, Vol.31 (1), p.15-20
Hauptverfasser:	Barradas, M.A., Mikhailidis, D.P., Dandona, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADPase Apyrase - blood Apyrase - physiology Biological and medical sciences Fatty Acids, Nonesterified - blood Female Fetal Blood - analysis Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans Phosphoric Monoester Hydrolases - blood Placenta Platelet Aggregation Pregnancy Pregnancy - blood Pregnancy Complications, Cardiovascular - etiology Pregnancy. Parturition. Lactation Thrombosis - etiology Umbilical cord Vertebrates: reproduction
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Zusammenfassung:	ADPase enzyme activity was assessed in maternal and cord plasma by adding radio-labelled ADP and quantitating the degradation products. Cord plasma had sufficiently greater ADPase activity than the corresponding maternal plasma obtained ante- and post-partum. Thus, residual radiolabelled ADP was 30, 32 and 17% of total radioactivity after 30 min incubation (37°C) in maternal ante-partum, maternal post-partum and cord plasmas, respectively. ADPase may act as a platelet aggregation inhibitor in the placental and fetal circulation.
ISSN:	0020-7292 1879-3479
DOI:	10.1016/0020-7292(90)90175-K