Na+-H+ Antiport Activity in Skin Fibroblasts from Blacks and Whites

The predisposition of black people to salt (NaCl) -sensitive essential hypertension may relate to racial differences in cellular Na+ metabolism. This tenet was investigated by examining the Na+-H+ antiport in serially passed skin fibroblasts from blacks and whites. Na+-dependent stimulation of the N...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1990-02, Vol.15 (2), p.140-145
Hauptverfasser:	Hatori, Norio, Gardner, Jeffrey P, Tomonari, Haruo, Fine, Burton P, Aviv, Abraham
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Continental Ancestry Group Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carrier Proteins - analysis Clinical manifestations. Epidemiology. Investigative techniques. Etiology European Continental Ancestry Group Female Fibroblasts - analysis Humans Hydrogen-Ion Concentration Male Medical sciences Skin - analysis Sodium - metabolism Sodium-Hydrogen Exchangers
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Zusammenfassung:	The predisposition of black people to salt (NaCl) -sensitive essential hypertension may relate to racial differences in cellular Na+ metabolism. This tenet was investigated by examining the Na+-H+ antiport in serially passed skin fibroblasts from blacks and whites. Na+-dependent stimulation of the Na+-H+ antiport by cellular acidification resulted in a greater maximal velocity (V (mean±SEM) of this transport system in quiescent fibroblasts from blacks than fibroblasts from whites; the V ⁁ for recovery from cellular pH (pHJ of 6.6 was 5.84±0.50 versus 439±034 mmol H+/lx20 seconds for blacks and whites, respectively (/?
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.15.2.140