Trisomy 12 in uterine leiomyomas: A new cytogenetic subgroup
Chromosome analysis of short-term cultures from uterine leiomyomas revealed trisomy 12 in six cases. In four of the tumors + 12 was the only karyotypic change. The fifth case also had trisomy 4, whereas the sixth had loss of one X chromosome as an additional aberration. These findings indicate that...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1990-03, Vol.45 (1), p.63-66 |
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| container_title | Cancer genetics and cytogenetics |
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| creator | Nilbert, Mef Heim, Sverre Mandahl, Nils Flodérus, Ulla-Maria Willén, Helena Mitelman, Felix |
| description | Chromosome analysis of short-term cultures from uterine leiomyomas revealed trisomy 12 in six cases. In four of the tumors + 12 was the only karyotypic change. The fifth case also had trisomy 4, whereas the sixth had loss of one X chromosome as an additional aberration. These findings indicate that trisomy 12 characterizes a new cytogenetic subgroup of uterine leiomyoma. |
| doi_str_mv | 10.1016/0165-4608(90)90067-K |
| format | Article |
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In four of the tumors + 12 was the only karyotypic change. The fifth case also had trisomy 4, whereas the sixth had loss of one X chromosome as an additional aberration. These findings indicate that trisomy 12 characterizes a new cytogenetic subgroup of uterine leiomyoma.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/0165-4608(90)90067-K</identifier><identifier>PMID: 2302686</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; chromosome 12 ; Chromosomes, Human, Pair 12 ; Female ; Female genital diseases ; Gynecology. Andrology. 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Obstetrics</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leiomyoma - genetics</subject><subject>Medical sciences</subject><subject>Trisomy</subject><subject>Tumors</subject><subject>Uterine Neoplasms - genetics</subject><subject>uterus</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEQgIMotT7-gcJeFD2sTpJNdiMilOKLFrz0HrLZaYnsoya7Sv-9u7b06mEYmPkYZuYj5ILCHQUq7_sQcSIhu1FwqwBkGs8OyJhmKY-TRMhDMt4jx-QkhE8ASJmSIzJiHJjM5Jg8LrwLTbWJKItcHXUteldjVKLri01lwkM0iWr8ieymbVZYY-tsFLp85ZtufUaOlqYMeL7Lp2Tx8ryYvsXzj9f36WQeI2esjZlljC4TsEplOc9tLiSYQkCaCJopKbkBAUpRaVHxRCZmaQQtCsBUYi4MPyXX27Fr33x1GFpduWCxLE2NTRd0qiTljPJ_QSpkwhgM4OUO7PIKC732rjJ-o3dv6ftXu74J1pRLb2rrwh6jijPe795zT1sO--u_HXodrMPaYuE82lYXjdMU9KBLDy704EIr0H-69Iz_Auqsg84</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>Nilbert, Mef</creator><creator>Heim, Sverre</creator><creator>Mandahl, Nils</creator><creator>Flodérus, Ulla-Maria</creator><creator>Willén, Helena</creator><creator>Mitelman, Felix</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19900301</creationdate><title>Trisomy 12 in uterine leiomyomas: A new cytogenetic subgroup</title><author>Nilbert, Mef ; Heim, Sverre ; Mandahl, Nils ; Flodérus, Ulla-Maria ; Willén, Helena ; Mitelman, Felix</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e322t-2c221f40c998b3bcb560ad50745189663a0509916ce93464afa51dd0e76eb5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Biological and medical sciences</topic><topic>chromosome 12</topic><topic>Chromosomes, Human, Pair 12</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. 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| ispartof | Cancer genetics and cytogenetics, 1990-03, Vol.45 (1), p.63-66 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences chromosome 12 Chromosomes, Human, Pair 12 Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Karyotyping Leiomyoma - genetics Medical sciences Trisomy Tumors Uterine Neoplasms - genetics uterus |
| title | Trisomy 12 in uterine leiomyomas: A new cytogenetic subgroup |
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