Trisomy 12 in uterine leiomyomas: A new cytogenetic subgroup

Chromosome analysis of short-term cultures from uterine leiomyomas revealed trisomy 12 in six cases. In four of the tumors + 12 was the only karyotypic change. The fifth case also had trisomy 4, whereas the sixth had loss of one X chromosome as an additional aberration. These findings indicate that...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1990-03, Vol.45 (1), p.63-66
Hauptverfasser:	Nilbert, Mef, Heim, Sverre, Mandahl, Nils, Flodérus, Ulla-Maria, Willén, Helena, Mitelman, Felix
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences chromosome 12 Chromosomes, Human, Pair 12 Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Karyotyping Leiomyoma - genetics Medical sciences Trisomy Tumors Uterine Neoplasms - genetics uterus
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Zusammenfassung:	Chromosome analysis of short-term cultures from uterine leiomyomas revealed trisomy 12 in six cases. In four of the tumors + 12 was the only karyotypic change. The fifth case also had trisomy 4, whereas the sixth had loss of one X chromosome as an additional aberration. These findings indicate that trisomy 12 characterizes a new cytogenetic subgroup of uterine leiomyoma.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(90)90067-K