2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A Neuroprotectant for Cerebral Ischemia

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the quinoxalinedione antagonists to the non-N-methyl-D-aspartate (non-NMDA) glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at t...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1990-02, Vol.247 (4942), p.571-574
Hauptverfasser:	Sheardown, Malcolm J., Nielsen, Elsebet Ø., Hansen, Anker J., Jacobsen, Poul, Honoré, Tage
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid AMPA receptors Animals Aspartic Acid - analogs & derivatives Aspartic Acid - pharmacology Biological and medical sciences Brain Brain ischemia Brain Ischemia - drug therapy Cerebral Cortex - drug effects Cerebral Cortex - physiology Dose response relationship Excitatory amino acid antagonists Hippocampus - drug effects Hippocampus - physiology Hippocampus - physiopathology Ibotenic Acid - analogs & derivatives Ibotenic Acid - pharmacology In Vitro Techniques Inhibitory concentration 50 Ischemia Kainic Acid - pharmacology Medical sciences Miscellaneous N-Methylaspartate Neurons Neurons - drug effects Neurons - physiology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Oxadiazoles - pharmacology Pharmacology. Drug treatments Pyramidal Tracts - drug effects Pyramidal Tracts - physiology Pyramidal Tracts - physiopathology Quinoxalines - metabolism Quinoxalines - pharmacology Quinoxalines - therapeutic use Quisqualic Acid Rats Receptors Receptors, Glutamate Receptors, Kainic Acid Receptors, Neurotransmitter - drug effects Receptors, Neurotransmitter - metabolism Science
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Beschreibung
Zusammenfassung:	2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the quinoxalinedione antagonists to the non-N-methyl-D-aspartate (non-NMDA) glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine sites. NBQX protects against global ischemia, even when administered 2 hours after an ischemic challenge.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.2154034