CONCENTRATION OF LEVOFLOXACIN IN CERVICAL MUCUS AND ITS CLINICAL EFFECTS ON CERVICITIS

An investigation was made on the concentration of levofloxacin (LVFX) in cervical mucus and its clinical effects on cervicitis. The results were as follows: 1) The concentrations of orally administered LVFX in the cervical mucus of 110 subjects were determined by HPLC. During 1-4 hour after the administration the mean concentration of LVFX in the cervical mucus reached a level of 2μg/g, which was higher than the serum level. The transfer of LVFX to the cervical mucus was almost the same as that to other genital organs. 2) When LVFX was given to 102 patients at a dose of 100-200mg, t.i.d. for 4-15 days and 872 (18) THE JAPANESE JOURNAL OF ANTIBIOTICS 50-11 Nov. 1997 the efficacy was evaluated with clinical improvement, the clinical efficacy rate of LVFX was 72/102 (70.6%). Significant bacteriological effects were observed in 70/73 (95.9%), especially, the disappear-ance rate of C. trachomatis was 18/18 (100%). 3) The administration of LVFX did not cause any subjective or objective side effects and any abnormalities were not detected in the laboratory tests done in this study. These results demonstrate that LVFX can be sufficiently transferred to the cervical mucus for the treatment of cervicitis due to the infection of C. trachomatis etc.