Reduction of Ischemic K+ Loss and Arrhythmias in Rat Hearts: Effect of Glibenclamide, a Sulfonylurea

Reduction of Ischemic K+ Loss and Arrhythmias in Rat Hearts: Effect of Glibenclamide, a Sulfonylurea

Glibenclamide, one of the antidiabetic sulfonylureas, is known to block ATP-dependent K channels. We used this drug to determine to what extent K loss from acutely ischemic myocardium is mediated via these channels. We also investigated whether glibenclamide would influence ischemic arrhythmias. Iso...

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Veröffentlicht in:Circulation research 1990-02, Vol.66 (2), p.478-485
Hauptverfasser: Kantor, Paul F, Coetzee, William A, Carmeliet, Edward E, Dennis, Steven C, Opie, Lionel H
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Arrhythmias, Cardiac - prevention & control
Biological and medical sciences
Coronary Disease - metabolism
Fundamental and applied biological sciences. Psychology
Glyburide - pharmacology
Heart
Heart - drug effects
Heart - physiopathology
Lactates - metabolism
Lactic Acid
Male
Myocardium - metabolism
Potassium - metabolism
Rats
Rats, Inbred Strains
Vertebrates: cardiovascular system
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Zusammenfassung:Glibenclamide, one of the antidiabetic sulfonylureas, is known to block ATP-dependent K channels. We used this drug to determine to what extent K loss from acutely ischemic myocardium is mediated via these channels. We also investigated whether glibenclamide would influence ischemic arrhythmias. Isolated rat hearts rendered globally ischemic showed no correlation between early lactate and K efflux rates. Cumulative Kʼ loss during 11 minutes of global ischemia (0.5 ml min g) was reduced, from 3.2±0.3 to 2.5±0.1 μeq/g (p
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.66.2.478