Comparison of gas—liquid chromatography and fluorescence polarization immunoassay for therapeutic drug monitoring of flecainide acetate

Comparison of gas—liquid chromatography and fluorescence polarization immunoassay for therapeutic drug monitoring of flecainide acetate

A gas chromatographic (GC) method for quantitation of flecainide acetate in human plasma is described and compared with a fluorescence polarization immunoassay (FPIA) for therapeutic drug monitoring. The GC method includes a solid-phase extraction procedure and electron capture detection (ECD) witho...

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Veröffentlicht in:Journal of pharmaceutical and biomedical analysis 1989, Vol.7 (12), p.1651-1656
Hauptverfasser: Stas, C.M., Jacqmin, P.A., Pellegrin, P.L.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Biological and medical sciences
Chromatography, Gas
flecainide
Flecainide - analysis
Flecainide - blood
Fluorescence Polarization Immunoassay
fluorescence polarization immunoassay (FPIA)
Gas chromatography assay
General pharmacology
Humans
Indicators and Reagents
Medical sciences
Pharmacology. Drug treatments
therapeutic drug monitoring
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Zusammenfassung:A gas chromatographic (GC) method for quantitation of flecainide acetate in human plasma is described and compared with a fluorescence polarization immunoassay (FPIA) for therapeutic drug monitoring. The GC method includes a solid-phase extraction procedure and electron capture detection (ECD) without the need of derivatization. Within-day and between-day coefficients of variation were
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(89)80178-5