Philanthotoxins. A mass spectrometric investigation
A method employing liquid secondary‐ion mass spectrometry (SIMS) in conjunction with metastable‐ion measurements (linked scanning at constant B/E) to obtain sequence‐specific information for three synthetic polyamine isomers was developed. The normal liquid SIMS spectra gave molecular weight informa...
Gespeichert in:
| Veröffentlicht in: | Rapid communications in mass spectrometry 1989-09, Vol.3 (9), p.295-297 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 297 |
|---|---|
| container_issue | 9 |
| container_start_page | 295 |
| container_title | Rapid communications in mass spectrometry |
| container_volume | 3 |
| creator | Kenny, Peter T. M. Goodnow Jr, Robert A Konno, Katsuhiro Nakanishi, Koji |
| description | A method employing liquid secondary‐ion mass spectrometry (SIMS) in conjunction with metastable‐ion measurements (linked scanning at constant B/E) to obtain sequence‐specific information for three synthetic polyamine isomers was developed. The normal liquid SIMS spectra gave molecular weight information, but important sequence ions were of low intensity or obscured by the background. The metastable‐ion spectra contained important fragment ions in particular due to cleavage along the polyamine chain. One of the three synthetic isomers was identical with a toxin present in the venom of the digger wasp. In conjunction with nuclear magnetic resonance spectroscopic studies, this should be a powerful method for the structural characterization of other closely related toxins present in the venom of this wasp. |
| doi_str_mv | 10.1002/rcm.1290030906 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79580219</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79580219</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2936-3a110f819cda4c3269a3ad0ca97ffc6c28e6210ca4458edf3405911d07b1f9443</originalsourceid><addsrcrecordid>eNqFkEtPwzAQhC0EKqVw5YaUE7eEXdt5-FhVtIDKQzzUo-U6DjUkTbFTaP89Qa2KOHFarWbm29UQcooQIQC9cLqKkAoABgKSPdJFEGkIlOE-6YKIMeQoskNy5P0bAGJMoUM6NE4oj7FL2MPMlmrezOqmXtm5j4J-UCnvA78wunF1ZRpndWDnn8Y39lU1tp4fk4NCld6cbGePvAwvnwdX4fh-dD3oj0NNBUtCphChyFDoXHHNaCIUUzloJdKi0ImmmUkotjvncWbygnGIBWIO6RQLwTnrkfMNd-Hqj2V7X1bWa1O2_5p66WUq4gwoitYYbYza1d47U8iFs5Vya4kgf1qSbUvyt6U2cLYlL6eVyXf2bS2tLjb6ly3N-h-afBzc_mGHm6z1jVntssq9yyRlaSwndyP5NJrQIadDecO-AceagdY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79580219</pqid></control><display><type>article</type><title>Philanthotoxins. A mass spectrometric investigation</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kenny, Peter T. M. ; Goodnow Jr, Robert A ; Konno, Katsuhiro ; Nakanishi, Koji</creator><creatorcontrib>Kenny, Peter T. M. ; Goodnow Jr, Robert A ; Konno, Katsuhiro ; Nakanishi, Koji</creatorcontrib><description>A method employing liquid secondary‐ion mass spectrometry (SIMS) in conjunction with metastable‐ion measurements (linked scanning at constant B/E) to obtain sequence‐specific information for three synthetic polyamine isomers was developed. The normal liquid SIMS spectra gave molecular weight information, but important sequence ions were of low intensity or obscured by the background. The metastable‐ion spectra contained important fragment ions in particular due to cleavage along the polyamine chain. One of the three synthetic isomers was identical with a toxin present in the venom of the digger wasp. In conjunction with nuclear magnetic resonance spectroscopic studies, this should be a powerful method for the structural characterization of other closely related toxins present in the venom of this wasp.</description><identifier>ISSN: 0951-4198</identifier><identifier>EISSN: 1097-0231</identifier><identifier>DOI: 10.1002/rcm.1290030906</identifier><identifier>PMID: 2562451</identifier><language>eng</language><publisher>London: Heyden & Son Limited</publisher><subject>Isomerism ; Mass Spectrometry - methods ; Receptors, Glutamate ; Receptors, Neurotransmitter - antagonists & inhibitors ; Wasp Venoms - chemistry</subject><ispartof>Rapid communications in mass spectrometry, 1989-09, Vol.3 (9), p.295-297</ispartof><rights>Copyright © 1989 Heyden & Son Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2936-3a110f819cda4c3269a3ad0ca97ffc6c28e6210ca4458edf3405911d07b1f9443</citedby><cites>FETCH-LOGICAL-c2936-3a110f819cda4c3269a3ad0ca97ffc6c28e6210ca4458edf3405911d07b1f9443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Frcm.1290030906$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Frcm.1290030906$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2562451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kenny, Peter T. M.</creatorcontrib><creatorcontrib>Goodnow Jr, Robert A</creatorcontrib><creatorcontrib>Konno, Katsuhiro</creatorcontrib><creatorcontrib>Nakanishi, Koji</creatorcontrib><title>Philanthotoxins. A mass spectrometric investigation</title><title>Rapid communications in mass spectrometry</title><addtitle>Rapid Commun. Mass Spectrom</addtitle><description>A method employing liquid secondary‐ion mass spectrometry (SIMS) in conjunction with metastable‐ion measurements (linked scanning at constant B/E) to obtain sequence‐specific information for three synthetic polyamine isomers was developed. The normal liquid SIMS spectra gave molecular weight information, but important sequence ions were of low intensity or obscured by the background. The metastable‐ion spectra contained important fragment ions in particular due to cleavage along the polyamine chain. One of the three synthetic isomers was identical with a toxin present in the venom of the digger wasp. In conjunction with nuclear magnetic resonance spectroscopic studies, this should be a powerful method for the structural characterization of other closely related toxins present in the venom of this wasp.</description><subject>Isomerism</subject><subject>Mass Spectrometry - methods</subject><subject>Receptors, Glutamate</subject><subject>Receptors, Neurotransmitter - antagonists & inhibitors</subject><subject>Wasp Venoms - chemistry</subject><issn>0951-4198</issn><issn>1097-0231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EKqVw5YaUE7eEXdt5-FhVtIDKQzzUo-U6DjUkTbFTaP89Qa2KOHFarWbm29UQcooQIQC9cLqKkAoABgKSPdJFEGkIlOE-6YKIMeQoskNy5P0bAGJMoUM6NE4oj7FL2MPMlmrezOqmXtm5j4J-UCnvA78wunF1ZRpndWDnn8Y39lU1tp4fk4NCld6cbGePvAwvnwdX4fh-dD3oj0NNBUtCphChyFDoXHHNaCIUUzloJdKi0ImmmUkotjvncWbygnGIBWIO6RQLwTnrkfMNd-Hqj2V7X1bWa1O2_5p66WUq4gwoitYYbYza1d47U8iFs5Vya4kgf1qSbUvyt6U2cLYlL6eVyXf2bS2tLjb6ly3N-h-afBzc_mGHm6z1jVntssq9yyRlaSwndyP5NJrQIadDecO-AceagdY</recordid><startdate>198909</startdate><enddate>198909</enddate><creator>Kenny, Peter T. M.</creator><creator>Goodnow Jr, Robert A</creator><creator>Konno, Katsuhiro</creator><creator>Nakanishi, Koji</creator><general>Heyden & Son Limited</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198909</creationdate><title>Philanthotoxins. A mass spectrometric investigation</title><author>Kenny, Peter T. M. ; Goodnow Jr, Robert A ; Konno, Katsuhiro ; Nakanishi, Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2936-3a110f819cda4c3269a3ad0ca97ffc6c28e6210ca4458edf3405911d07b1f9443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Isomerism</topic><topic>Mass Spectrometry - methods</topic><topic>Receptors, Glutamate</topic><topic>Receptors, Neurotransmitter - antagonists & inhibitors</topic><topic>Wasp Venoms - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kenny, Peter T. M.</creatorcontrib><creatorcontrib>Goodnow Jr, Robert A</creatorcontrib><creatorcontrib>Konno, Katsuhiro</creatorcontrib><creatorcontrib>Nakanishi, Koji</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rapid communications in mass spectrometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kenny, Peter T. M.</au><au>Goodnow Jr, Robert A</au><au>Konno, Katsuhiro</au><au>Nakanishi, Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Philanthotoxins. A mass spectrometric investigation</atitle><jtitle>Rapid communications in mass spectrometry</jtitle><addtitle>Rapid Commun. Mass Spectrom</addtitle><date>1989-09</date><risdate>1989</risdate><volume>3</volume><issue>9</issue><spage>295</spage><epage>297</epage><pages>295-297</pages><issn>0951-4198</issn><eissn>1097-0231</eissn><abstract>A method employing liquid secondary‐ion mass spectrometry (SIMS) in conjunction with metastable‐ion measurements (linked scanning at constant B/E) to obtain sequence‐specific information for three synthetic polyamine isomers was developed. The normal liquid SIMS spectra gave molecular weight information, but important sequence ions were of low intensity or obscured by the background. The metastable‐ion spectra contained important fragment ions in particular due to cleavage along the polyamine chain. One of the three synthetic isomers was identical with a toxin present in the venom of the digger wasp. In conjunction with nuclear magnetic resonance spectroscopic studies, this should be a powerful method for the structural characterization of other closely related toxins present in the venom of this wasp.</abstract><cop>London</cop><pub>Heyden & Son Limited</pub><pmid>2562451</pmid><doi>10.1002/rcm.1290030906</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0951-4198 |
| ispartof | Rapid communications in mass spectrometry, 1989-09, Vol.3 (9), p.295-297 |
| issn | 0951-4198 1097-0231 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79580219 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Isomerism Mass Spectrometry - methods Receptors, Glutamate Receptors, Neurotransmitter - antagonists & inhibitors Wasp Venoms - chemistry |
| title | Philanthotoxins. A mass spectrometric investigation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T05%3A31%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Philanthotoxins.%20A%20mass%20spectrometric%20investigation&rft.jtitle=Rapid%20communications%20in%20mass%20spectrometry&rft.au=Kenny,%20Peter%20T.%20M.&rft.date=1989-09&rft.volume=3&rft.issue=9&rft.spage=295&rft.epage=297&rft.pages=295-297&rft.issn=0951-4198&rft.eissn=1097-0231&rft_id=info:doi/10.1002/rcm.1290030906&rft_dat=%3Cproquest_cross%3E79580219%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79580219&rft_id=info:pmid/2562451&rfr_iscdi=true |