A recombinant homotrimer of type I procollagen that lacks the central two D-periods. The thermal stability of the triple helix is decreased by 2 to 4 degrees C

A D-period cassette system was developed that can be used to synthesize a variety of recombinant homotrimers of type I procollagen. A construct lacking the central two D-periods of pro alpha 1(I) chains was assembled and expressed as a recombinant protein in the mammalian cell line. The recombinant...

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Veröffentlicht in:Matrix biology 1997-11, Vol.16 (5), p.245-253
Hauptverfasser: Zafarullah, K, Sieron, A L, Fertala, A, Tromp, G, Kuivaniemi, H, Prockop, D J
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Sprache:eng
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