Increased Epinephrine-Induced cAMP Response in Severely Diabetic BB/W Rat Liver
The effect of prolonged diabetes on epinephrine-induced adenosine 3', 5'-monophosphate (cAMP) response in the liver was examined in diabetes-prone BB/W rats. Basal and 1μM epinephrine- induced cAMP release from isolated perfused liver was similar in non-diabetic and diabetic BB/W rats with...
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| Veröffentlicht in: | ENDOCRINE JOURNAL 1997, Vol.44(5), pp.725-732 |
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| creator | YAMATANI, KEIICHI SAITO, KIMIHITO OHNUMA, HIROSHI IKEZAWA, YOSHIHIRO SEINO, TOMOMI MANAKA, YUKIKO DAIMON, MAKOTO TAKAHASHI, KENJI SASAKI, HIDEO |
| description | The effect of prolonged diabetes on epinephrine-induced adenosine 3', 5'-monophosphate (cAMP) response in the liver was examined in diabetes-prone BB/W rats. Basal and 1μM epinephrine- induced cAMP release from isolated perfused liver was similar in non-diabetic and diabetic BB/W rats with preserved adipose tissue. In adipose tissue-absent diabetic rats losing intra- and retro-peritoneal adipose tissue completely, both basal and 1μM epinephrine-induced cAMP release from the liver were enhanced (P |
| doi_str_mv | 10.1507/endocrj.44.725 |
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Basal and 1μM epinephrine- induced cAMP release from isolated perfused liver was similar in non-diabetic and diabetic BB/W rats with preserved adipose tissue. In adipose tissue-absent diabetic rats losing intra- and retro-peritoneal adipose tissue completely, both basal and 1μM epinephrine-induced cAMP release from the liver were enhanced (P<0.01, each case). Plasma epinephrine and norepinephrine were similar in non-diabetic, adipose tissue-preserved and -absent diabetic BB/W rats. The plasma free thyroxine level was similar in non-diabetic and adipose tissue-preserved diabetic BB/W rats, but was lower in adipose tissue-absent diabetic BB/W rats than in non-diabetic rats (P<0.01), but the frequency of lymphocytic thyroiditis was similar in these three groups, although plasma corticosterone was lower in adipose tissue-preserved diabetic BB/W rats (P<0.05) and the lowest in adipose tissue-absent diabetic BB/W rats (P<0.01). Lymphocytic infiltration was not observed in the adrenal or pituitary glands in any group. Plasma total protein and albumin were low in adipose tissue-absent diabetic BB/W rats (P<0.01, each case). In adipose tissue-absent diabetic BB/W rats, liver dysfunction and hepatomegaly, but no apparent histological change in the liver, were observed. Plasma glucose was higher (P<0.01) and plasma insulin lower (P<0.05) in adipose tissue-absent diabetic BB/W rats than in adipose tissue-preserved diabetic BB/ W rats. In conclusion, epinephrine-induced cAMP response in the liver was enhanced only in adipose tissue-absent diabetic BB/W rats. Denervation supersensitivity was not likely to be responsible for the enhanced β-adrenergic response. The observed reductions in plasma thyroxine and corticosterone seemed to result from severe diabetes. Although the severity of diabetes can vary continuously, severe diabetes with loss of adipose tissue appeared to cause significant changes in the metabolism and enhanced β-adrenergic response in the liver.]]></description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.44.725</identifier><identifier>PMID: 9466330</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Adenosine 3',5'-monophosphate (cAMP) ; Adipose tissue ; Alanine Transaminase - blood ; Animals ; Aspartate Aminotransferases - blood ; BB/W rat ; Blood Glucose - analysis ; Cohort Studies ; Corticosterone - blood ; Cyclic AMP - metabolism ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - pathology ; Epinephrine ; Epinephrine - blood ; Epinephrine - pharmacology ; Glucagon - blood ; Glucose - metabolism ; Insulin - blood ; Liver - drug effects ; Liver - enzymology ; Liver - metabolism ; Liver dysfunction ; Male ; Pancreas - pathology ; Perfusion ; Rats ; Rats, Inbred BB ; Rats, Wistar ; Thyroxine - blood ; Time Factors</subject><ispartof>Endocrine Journal, 1997, Vol.44(5), pp.725-732</ispartof><rights>The Japan Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c685t-b245127d44f173169309c67111bf52d078e90151587ec08d969f2676b39c1b673</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9466330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YAMATANI, KEIICHI</creatorcontrib><creatorcontrib>SAITO, KIMIHITO</creatorcontrib><creatorcontrib>OHNUMA, HIROSHI</creatorcontrib><creatorcontrib>IKEZAWA, YOSHIHIRO</creatorcontrib><creatorcontrib>SEINO, TOMOMI</creatorcontrib><creatorcontrib>MANAKA, YUKIKO</creatorcontrib><creatorcontrib>DAIMON, MAKOTO</creatorcontrib><creatorcontrib>TAKAHASHI, KENJI</creatorcontrib><creatorcontrib>SASAKI, HIDEO</creatorcontrib><creatorcontrib>The Third Department of Internal Medicine</creatorcontrib><creatorcontrib>Yamagata University School of Medicine</creatorcontrib><creatorcontrib>Department of Radiology</creatorcontrib><title>Increased Epinephrine-Induced cAMP Response in Severely Diabetic BB/W Rat Liver</title><title>ENDOCRINE JOURNAL</title><addtitle>Endocr J</addtitle><description><![CDATA[The effect of prolonged diabetes on epinephrine-induced adenosine 3', 5'-monophosphate (cAMP) response in the liver was examined in diabetes-prone BB/W rats. Basal and 1μM epinephrine- induced cAMP release from isolated perfused liver was similar in non-diabetic and diabetic BB/W rats with preserved adipose tissue. In adipose tissue-absent diabetic rats losing intra- and retro-peritoneal adipose tissue completely, both basal and 1μM epinephrine-induced cAMP release from the liver were enhanced (P<0.01, each case). Plasma epinephrine and norepinephrine were similar in non-diabetic, adipose tissue-preserved and -absent diabetic BB/W rats. The plasma free thyroxine level was similar in non-diabetic and adipose tissue-preserved diabetic BB/W rats, but was lower in adipose tissue-absent diabetic BB/W rats than in non-diabetic rats (P<0.01), but the frequency of lymphocytic thyroiditis was similar in these three groups, although plasma corticosterone was lower in adipose tissue-preserved diabetic BB/W rats (P<0.05) and the lowest in adipose tissue-absent diabetic BB/W rats (P<0.01). Lymphocytic infiltration was not observed in the adrenal or pituitary glands in any group. Plasma total protein and albumin were low in adipose tissue-absent diabetic BB/W rats (P<0.01, each case). In adipose tissue-absent diabetic BB/W rats, liver dysfunction and hepatomegaly, but no apparent histological change in the liver, were observed. Plasma glucose was higher (P<0.01) and plasma insulin lower (P<0.05) in adipose tissue-absent diabetic BB/W rats than in adipose tissue-preserved diabetic BB/ W rats. In conclusion, epinephrine-induced cAMP response in the liver was enhanced only in adipose tissue-absent diabetic BB/W rats. Denervation supersensitivity was not likely to be responsible for the enhanced β-adrenergic response. The observed reductions in plasma thyroxine and corticosterone seemed to result from severe diabetes. Although the severity of diabetes can vary continuously, severe diabetes with loss of adipose tissue appeared to cause significant changes in the metabolism and enhanced β-adrenergic response in the liver.]]></description><subject>Adenosine 3',5'-monophosphate (cAMP)</subject><subject>Adipose tissue</subject><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>BB/W rat</subject><subject>Blood Glucose - analysis</subject><subject>Cohort Studies</subject><subject>Corticosterone - blood</subject><subject>Cyclic AMP - metabolism</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - pathology</subject><subject>Epinephrine</subject><subject>Epinephrine - blood</subject><subject>Epinephrine - pharmacology</subject><subject>Glucagon - blood</subject><subject>Glucose - metabolism</subject><subject>Insulin - blood</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - metabolism</subject><subject>Liver dysfunction</subject><subject>Male</subject><subject>Pancreas - pathology</subject><subject>Perfusion</subject><subject>Rats</subject><subject>Rats, Inbred BB</subject><subject>Rats, Wistar</subject><subject>Thyroxine - blood</subject><subject>Time Factors</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAURi0EKkNhyw4pK3aZXseveNkXZaRBRYWqS8txbmhGmSS1E6T-e-4w03bZzbXk7_OxdczYZw5LrsCcYF8PIW6WUi5Nod6wBReyzKWS8JYtwPIyL62y79mHlDYAQigpjtiRlVoLAQt2vepDRJ-wzi7HtsfxPtLMV309B9oLpz9-ZjeYxqFPmLV99gv_YsTuMbtofYVTG7Kzs5O77MZP2bql6CN71_gu4afDesxuv13-Pv-er6-vVuen6zzoUk15VUjFC1NL2XAjuLYCbNCGc141qqjBlGiBK65KgwHK2mrbFNroStjAK23EMfu6545xeJgxTW7bpoBd53sc5uSMVQq4lq8WqaMKckHF5b4Y4pBSxMaNsd36-Og4uJ1qd1DtpHSkmg58OZDnaov1c_3glvKrfU5hG3w39B2pdZthjj2pceFB_yc6bq1xAFKCcsCFA6LTEAWHkgToF9ImTf4PPt_kI31Ah08PI47YPU7tx47y1Aj3PlJN_ANGpqgb</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>YAMATANI, KEIICHI</creator><creator>SAITO, KIMIHITO</creator><creator>OHNUMA, HIROSHI</creator><creator>IKEZAWA, YOSHIHIRO</creator><creator>SEINO, TOMOMI</creator><creator>MANAKA, YUKIKO</creator><creator>DAIMON, MAKOTO</creator><creator>TAKAHASHI, KENJI</creator><creator>SASAKI, HIDEO</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Increased Epinephrine-Induced cAMP Response in Severely Diabetic BB/W Rat Liver</title><author>YAMATANI, KEIICHI ; SAITO, KIMIHITO ; OHNUMA, HIROSHI ; IKEZAWA, YOSHIHIRO ; SEINO, TOMOMI ; MANAKA, YUKIKO ; DAIMON, MAKOTO ; TAKAHASHI, KENJI ; SASAKI, HIDEO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c685t-b245127d44f173169309c67111bf52d078e90151587ec08d969f2676b39c1b673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adenosine 3',5'-monophosphate (cAMP)</topic><topic>Adipose tissue</topic><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Aspartate Aminotransferases - blood</topic><topic>BB/W rat</topic><topic>Blood Glucose - analysis</topic><topic>Cohort Studies</topic><topic>Corticosterone - blood</topic><topic>Cyclic AMP - metabolism</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - pathology</topic><topic>Epinephrine</topic><topic>Epinephrine - blood</topic><topic>Epinephrine - pharmacology</topic><topic>Glucagon - blood</topic><topic>Glucose - metabolism</topic><topic>Insulin - blood</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - metabolism</topic><topic>Liver dysfunction</topic><topic>Male</topic><topic>Pancreas - pathology</topic><topic>Perfusion</topic><topic>Rats</topic><topic>Rats, Inbred BB</topic><topic>Rats, Wistar</topic><topic>Thyroxine - blood</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YAMATANI, KEIICHI</creatorcontrib><creatorcontrib>SAITO, KIMIHITO</creatorcontrib><creatorcontrib>OHNUMA, HIROSHI</creatorcontrib><creatorcontrib>IKEZAWA, YOSHIHIRO</creatorcontrib><creatorcontrib>SEINO, TOMOMI</creatorcontrib><creatorcontrib>MANAKA, YUKIKO</creatorcontrib><creatorcontrib>DAIMON, MAKOTO</creatorcontrib><creatorcontrib>TAKAHASHI, KENJI</creatorcontrib><creatorcontrib>SASAKI, HIDEO</creatorcontrib><creatorcontrib>The Third Department of Internal Medicine</creatorcontrib><creatorcontrib>Yamagata University School of Medicine</creatorcontrib><creatorcontrib>Department of Radiology</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>ENDOCRINE JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YAMATANI, KEIICHI</au><au>SAITO, KIMIHITO</au><au>OHNUMA, HIROSHI</au><au>IKEZAWA, YOSHIHIRO</au><au>SEINO, TOMOMI</au><au>MANAKA, YUKIKO</au><au>DAIMON, MAKOTO</au><au>TAKAHASHI, KENJI</au><au>SASAKI, HIDEO</au><aucorp>The Third Department of Internal Medicine</aucorp><aucorp>Yamagata University School of Medicine</aucorp><aucorp>Department of Radiology</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Epinephrine-Induced cAMP Response in Severely Diabetic BB/W Rat Liver</atitle><jtitle>ENDOCRINE JOURNAL</jtitle><addtitle>Endocr J</addtitle><date>1997</date><risdate>1997</risdate><volume>44</volume><issue>5</issue><spage>725</spage><epage>732</epage><pages>725-732</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract><![CDATA[The effect of prolonged diabetes on epinephrine-induced adenosine 3', 5'-monophosphate (cAMP) response in the liver was examined in diabetes-prone BB/W rats. Basal and 1μM epinephrine- induced cAMP release from isolated perfused liver was similar in non-diabetic and diabetic BB/W rats with preserved adipose tissue. In adipose tissue-absent diabetic rats losing intra- and retro-peritoneal adipose tissue completely, both basal and 1μM epinephrine-induced cAMP release from the liver were enhanced (P<0.01, each case). Plasma epinephrine and norepinephrine were similar in non-diabetic, adipose tissue-preserved and -absent diabetic BB/W rats. The plasma free thyroxine level was similar in non-diabetic and adipose tissue-preserved diabetic BB/W rats, but was lower in adipose tissue-absent diabetic BB/W rats than in non-diabetic rats (P<0.01), but the frequency of lymphocytic thyroiditis was similar in these three groups, although plasma corticosterone was lower in adipose tissue-preserved diabetic BB/W rats (P<0.05) and the lowest in adipose tissue-absent diabetic BB/W rats (P<0.01). Lymphocytic infiltration was not observed in the adrenal or pituitary glands in any group. Plasma total protein and albumin were low in adipose tissue-absent diabetic BB/W rats (P<0.01, each case). In adipose tissue-absent diabetic BB/W rats, liver dysfunction and hepatomegaly, but no apparent histological change in the liver, were observed. Plasma glucose was higher (P<0.01) and plasma insulin lower (P<0.05) in adipose tissue-absent diabetic BB/W rats than in adipose tissue-preserved diabetic BB/ W rats. In conclusion, epinephrine-induced cAMP response in the liver was enhanced only in adipose tissue-absent diabetic BB/W rats. Denervation supersensitivity was not likely to be responsible for the enhanced β-adrenergic response. The observed reductions in plasma thyroxine and corticosterone seemed to result from severe diabetes. Although the severity of diabetes can vary continuously, severe diabetes with loss of adipose tissue appeared to cause significant changes in the metabolism and enhanced β-adrenergic response in the liver.]]></abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>9466330</pmid><doi>10.1507/endocrj.44.725</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenosine 3',5'-monophosphate (cAMP) Adipose tissue Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood BB/W rat Blood Glucose - analysis Cohort Studies Corticosterone - blood Cyclic AMP - metabolism Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - pathology Epinephrine Epinephrine - blood Epinephrine - pharmacology Glucagon - blood Glucose - metabolism Insulin - blood Liver - drug effects Liver - enzymology Liver - metabolism Liver dysfunction Male Pancreas - pathology Perfusion Rats Rats, Inbred BB Rats, Wistar Thyroxine - blood Time Factors |
| title | Increased Epinephrine-Induced cAMP Response in Severely Diabetic BB/W Rat Liver |
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