Increased Epinephrine-Induced cAMP Response in Severely Diabetic BB/W Rat Liver

The effect of prolonged diabetes on epinephrine-induced adenosine 3', 5'-monophosphate (cAMP) response in the liver was examined in diabetes-prone BB/W rats. Basal and 1μM epinephrine- induced cAMP release from isolated perfused liver was similar in non-diabetic and diabetic BB/W rats with...

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Veröffentlicht in:	ENDOCRINE JOURNAL 1997, Vol.44(5), pp.725-732
Hauptverfasser:	YAMATANI, KEIICHI, SAITO, KIMIHITO, OHNUMA, HIROSHI, IKEZAWA, YOSHIHIRO, SEINO, TOMOMI, MANAKA, YUKIKO, DAIMON, MAKOTO, TAKAHASHI, KENJI, SASAKI, HIDEO
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine 3',5'-monophosphate (cAMP) Adipose tissue Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood BB/W rat Blood Glucose - analysis Cohort Studies Corticosterone - blood Cyclic AMP - metabolism Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - pathology Epinephrine Epinephrine - blood Epinephrine - pharmacology Glucagon - blood Glucose - metabolism Insulin - blood Liver - drug effects Liver - enzymology Liver - metabolism Liver dysfunction Male Pancreas - pathology Perfusion Rats Rats, Inbred BB Rats, Wistar Thyroxine - blood Time Factors
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Zusammenfassung:	The effect of prolonged diabetes on epinephrine-induced adenosine 3', 5'-monophosphate (cAMP) response in the liver was examined in diabetes-prone BB/W rats. Basal and 1μM epinephrine- induced cAMP release from isolated perfused liver was similar in non-diabetic and diabetic BB/W rats with preserved adipose tissue. In adipose tissue-absent diabetic rats losing intra- and retro-peritoneal adipose tissue completely, both basal and 1μM epinephrine-induced cAMP release from the liver were enhanced (P
ISSN:	0918-8959 1348-4540
DOI:	10.1507/endocrj.44.725