Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever
Interleukins (IL)-1β and -1α and tumor necrosis factor (TNF-α) were measured by radioimmunoassay in plasma samples from 44 healthy individuals, 15 patients in septic shock, and 6 volunteers infused with endotoxin. Plasma IL-1α levels were low (40 pg/ml) or undetectable in all situations. In 67% ofth...
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| Veröffentlicht in: | The Journal of infectious diseases 1990-01, Vol.161 (1), p.79-84 |
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| container_title | The Journal of infectious diseases |
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| creator | Cannon, Joseph G. Tompkins, Ronald G. Gelfand, Jeffrey A. Michie, Hamish R. Stanford, Gregory G. van der Meer, Jos W. M. Endres, Stefan Lonnemann, Gerhard Corsetti, John Chernow, Bart Wilmore, Douglas W. Wolff, Sheldon M. Burke, John F. Dinarello, Charles A. |
| description | Interleukins (IL)-1β and -1α and tumor necrosis factor (TNF-α) were measured by radioimmunoassay in plasma samples from 44 healthy individuals, 15 patients in septic shock, and 6 volunteers infused with endotoxin. Plasma IL-1α levels were low (40 pg/ml) or undetectable in all situations. In 67% ofthe healthy subjects, plasma IL-1β levels were |
| doi_str_mv | 10.1093/infdis/161.1.79 |
| format | Article |
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M. ; Endres, Stefan ; Lonnemann, Gerhard ; Corsetti, John ; Chernow, Bart ; Wilmore, Douglas W. ; Wolff, Sheldon M. ; Burke, John F. ; Dinarello, Charles A.</creator><creatorcontrib>Cannon, Joseph G. ; Tompkins, Ronald G. ; Gelfand, Jeffrey A. ; Michie, Hamish R. ; Stanford, Gregory G. ; van der Meer, Jos W. M. ; Endres, Stefan ; Lonnemann, Gerhard ; Corsetti, John ; Chernow, Bart ; Wilmore, Douglas W. ; Wolff, Sheldon M. ; Burke, John F. ; Dinarello, Charles A.</creatorcontrib><description>Interleukins (IL)-1β and -1α and tumor necrosis factor (TNF-α) were measured by radioimmunoassay in plasma samples from 44 healthy individuals, 15 patients in septic shock, and 6 volunteers infused with endotoxin. Plasma IL-1α levels were low (40 pg/ml) or undetectable in all situations. In 67% ofthe healthy subjects, plasma IL-1β levels were <70 pg/ml. Septic patients had higher plasma IL-1β levels (120± 17pg/ml, P =.001);those of surviving patients were higher than those of patients who died (P = .05). Plasma TNF-α concentrations in septic individuals were elevated (119 ± 30 pg/ml) and correlated with severity of illness (r = .73, P = .003), but no correlation was observed between plasma IL-1β and TNF-α concentrations in individual samples. Infusion of endotoxin caused a twofold elevation of IL-1β, from a baseline of 35 ± 5 pg/ml to a maximum of 69 ± 27 pg/ml at 180min (P <.05). Peak TNF-a levels after endotoxin infusion were 15 times higher than IL-1β levels, were attained more rapidly (90 min), and as with the septic patients, did not correlate with IL-1β levels. These data support the concept that plasma IL-1β and TNF-α concentrations are regulated independently and are associated with different clinical outcomes.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/161.1.79</identifier><identifier>PMID: 2295861</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacterial diseases ; Biological and medical sciences ; Blood ; Blood plasma ; Cytokines ; Diseases ; Endotoxins ; Endotoxins - administration & dosage ; Female ; Fever ; Fever - blood ; Fever - chemically induced ; General aspects ; Humans ; Infectious diseases ; Interleukin-1 - blood ; Leukocytes ; Major Articles ; Male ; Medical sciences ; Middle Aged ; Radioimmunoassay ; Sepsis ; Septic shock ; Shock, Septic - blood ; Shock, Septic - mortality ; Tumor Necrosis Factor-alpha - metabolism ; Tumor necrosis factors</subject><ispartof>The Journal of infectious diseases, 1990-01, Vol.161 (1), p.79-84</ispartof><rights>Copyright 1990 The University of Chicago</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-fe653ceda4a46097604f898cae56afc0ea3bad3093a2a5b60d93fcba3d66771f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30119627$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30119627$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,4010,27900,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6767480$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2295861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cannon, Joseph G.</creatorcontrib><creatorcontrib>Tompkins, Ronald G.</creatorcontrib><creatorcontrib>Gelfand, Jeffrey A.</creatorcontrib><creatorcontrib>Michie, Hamish R.</creatorcontrib><creatorcontrib>Stanford, Gregory G.</creatorcontrib><creatorcontrib>van der Meer, Jos W. M.</creatorcontrib><creatorcontrib>Endres, Stefan</creatorcontrib><creatorcontrib>Lonnemann, Gerhard</creatorcontrib><creatorcontrib>Corsetti, John</creatorcontrib><creatorcontrib>Chernow, Bart</creatorcontrib><creatorcontrib>Wilmore, Douglas W.</creatorcontrib><creatorcontrib>Wolff, Sheldon M.</creatorcontrib><creatorcontrib>Burke, John F.</creatorcontrib><creatorcontrib>Dinarello, Charles A.</creatorcontrib><title>Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Interleukins (IL)-1β and -1α and tumor necrosis factor (TNF-α) were measured by radioimmunoassay in plasma samples from 44 healthy individuals, 15 patients in septic shock, and 6 volunteers infused with endotoxin. Plasma IL-1α levels were low (40 pg/ml) or undetectable in all situations. In 67% ofthe healthy subjects, plasma IL-1β levels were <70 pg/ml. Septic patients had higher plasma IL-1β levels (120± 17pg/ml, P =.001);those of surviving patients were higher than those of patients who died (P = .05). Plasma TNF-α concentrations in septic individuals were elevated (119 ± 30 pg/ml) and correlated with severity of illness (r = .73, P = .003), but no correlation was observed between plasma IL-1β and TNF-α concentrations in individual samples. Infusion of endotoxin caused a twofold elevation of IL-1β, from a baseline of 35 ± 5 pg/ml to a maximum of 69 ± 27 pg/ml at 180min (P <.05). Peak TNF-a levels after endotoxin infusion were 15 times higher than IL-1β levels, were attained more rapidly (90 min), and as with the septic patients, did not correlate with IL-1β levels. These data support the concept that plasma IL-1β and TNF-α concentrations are regulated independently and are associated with different clinical outcomes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood plasma</subject><subject>Cytokines</subject><subject>Diseases</subject><subject>Endotoxins</subject><subject>Endotoxins - administration & dosage</subject><subject>Female</subject><subject>Fever</subject><subject>Fever - blood</subject><subject>Fever - chemically induced</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interleukin-1 - blood</subject><subject>Leukocytes</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Radioimmunoassay</subject><subject>Sepsis</subject><subject>Septic shock</subject><subject>Shock, Septic - blood</subject><subject>Shock, Septic - mortality</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumor necrosis factors</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTFv2zAQhYmgReqknTMV0FB0k02KEimOhWvHAYx2SAoYXYgzdWoZy5RLUoHz78PUqtdOBPG-e4d7j5AbRqeMKj6zrm1smDHBpmwq1QWZsIrLXAjG35AJpUWRs1qpd-QqhEdKacmFvCSXRaGqWrAJaebWm6GDaN2v7M5F9B0OO-tyloFrsodh3_vsGxrfBxuyJZiY_tZl93iI1mT3v3uz-0sujgf0do8uQpctXNPH_pi4JT6hf0_ettAF_DC-1-THcvEwX-Xr77d38y_r3JSyjnmLouIGGyihFFRJQcu2VrUBrAS0hiLwLTQ8nQ0FVFtBG8VbswXeCCEla_k1-XzyPfj-z4Ah6r0NBrsOHPZD0FJVXJW1-C_IqrKWZU0TODuBrwEEj60-pCPBP2tG9WsB-lSATgVolhakiY-j9bDdY3Pmx8ST_mnUIRjoWg_OpPl_mJBiXDzaPIaU-FnmlDElCpn0_KTbEPF41sHvkgWXlV5tfurNer4pvy5X-pa_AMjhqU4</recordid><startdate>199001</startdate><enddate>199001</enddate><creator>Cannon, Joseph G.</creator><creator>Tompkins, Ronald G.</creator><creator>Gelfand, Jeffrey A.</creator><creator>Michie, Hamish R.</creator><creator>Stanford, Gregory G.</creator><creator>van der Meer, Jos W. M.</creator><creator>Endres, Stefan</creator><creator>Lonnemann, Gerhard</creator><creator>Corsetti, John</creator><creator>Chernow, Bart</creator><creator>Wilmore, Douglas W.</creator><creator>Wolff, Sheldon M.</creator><creator>Burke, John F.</creator><creator>Dinarello, Charles A.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>199001</creationdate><title>Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever</title><author>Cannon, Joseph G. ; Tompkins, Ronald G. ; Gelfand, Jeffrey A. ; Michie, Hamish R. ; Stanford, Gregory G. ; van der Meer, Jos W. M. ; Endres, Stefan ; Lonnemann, Gerhard ; Corsetti, John ; Chernow, Bart ; Wilmore, Douglas W. ; Wolff, Sheldon M. ; Burke, John F. ; Dinarello, Charles A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-fe653ceda4a46097604f898cae56afc0ea3bad3093a2a5b60d93fcba3d66771f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood plasma</topic><topic>Cytokines</topic><topic>Diseases</topic><topic>Endotoxins</topic><topic>Endotoxins - administration & dosage</topic><topic>Female</topic><topic>Fever</topic><topic>Fever - blood</topic><topic>Fever - chemically induced</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interleukin-1 - blood</topic><topic>Leukocytes</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Radioimmunoassay</topic><topic>Sepsis</topic><topic>Septic shock</topic><topic>Shock, Septic - blood</topic><topic>Shock, Septic - mortality</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumor necrosis factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cannon, Joseph G.</creatorcontrib><creatorcontrib>Tompkins, Ronald G.</creatorcontrib><creatorcontrib>Gelfand, Jeffrey A.</creatorcontrib><creatorcontrib>Michie, Hamish R.</creatorcontrib><creatorcontrib>Stanford, Gregory G.</creatorcontrib><creatorcontrib>van der Meer, Jos W. M.</creatorcontrib><creatorcontrib>Endres, Stefan</creatorcontrib><creatorcontrib>Lonnemann, Gerhard</creatorcontrib><creatorcontrib>Corsetti, John</creatorcontrib><creatorcontrib>Chernow, Bart</creatorcontrib><creatorcontrib>Wilmore, Douglas W.</creatorcontrib><creatorcontrib>Wolff, Sheldon M.</creatorcontrib><creatorcontrib>Burke, John F.</creatorcontrib><creatorcontrib>Dinarello, Charles A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cannon, Joseph G.</au><au>Tompkins, Ronald G.</au><au>Gelfand, Jeffrey A.</au><au>Michie, Hamish R.</au><au>Stanford, Gregory G.</au><au>van der Meer, Jos W. M.</au><au>Endres, Stefan</au><au>Lonnemann, Gerhard</au><au>Corsetti, John</au><au>Chernow, Bart</au><au>Wilmore, Douglas W.</au><au>Wolff, Sheldon M.</au><au>Burke, John F.</au><au>Dinarello, Charles A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1990-01</date><risdate>1990</risdate><volume>161</volume><issue>1</issue><spage>79</spage><epage>84</epage><pages>79-84</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Interleukins (IL)-1β and -1α and tumor necrosis factor (TNF-α) were measured by radioimmunoassay in plasma samples from 44 healthy individuals, 15 patients in septic shock, and 6 volunteers infused with endotoxin. Plasma IL-1α levels were low (40 pg/ml) or undetectable in all situations. In 67% ofthe healthy subjects, plasma IL-1β levels were <70 pg/ml. Septic patients had higher plasma IL-1β levels (120± 17pg/ml, P =.001);those of surviving patients were higher than those of patients who died (P = .05). Plasma TNF-α concentrations in septic individuals were elevated (119 ± 30 pg/ml) and correlated with severity of illness (r = .73, P = .003), but no correlation was observed between plasma IL-1β and TNF-α concentrations in individual samples. Infusion of endotoxin caused a twofold elevation of IL-1β, from a baseline of 35 ± 5 pg/ml to a maximum of 69 ± 27 pg/ml at 180min (P <.05). Peak TNF-a levels after endotoxin infusion were 15 times higher than IL-1β levels, were attained more rapidly (90 min), and as with the septic patients, did not correlate with IL-1β levels. These data support the concept that plasma IL-1β and TNF-α concentrations are regulated independently and are associated with different clinical outcomes.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>2295861</pmid><doi>10.1093/infdis/161.1.79</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1990-01, Vol.161 (1), p.79-84 |
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| language | eng |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adolescent Adult Aged Aged, 80 and over Bacterial diseases Biological and medical sciences Blood Blood plasma Cytokines Diseases Endotoxins Endotoxins - administration & dosage Female Fever Fever - blood Fever - chemically induced General aspects Humans Infectious diseases Interleukin-1 - blood Leukocytes Major Articles Male Medical sciences Middle Aged Radioimmunoassay Sepsis Septic shock Shock, Septic - blood Shock, Septic - mortality Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factors |
| title | Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever |
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