Palladium(II)-coproporphyrin I as a photoactivable group in sequence-specific modification of nucleic acids by oligonucleotide derivatives

The 34-mer oligodeoxynucleotide was shown to be selectively modified at the G17 position upon photoirradiation in the presence of complementary 17-mer oligodeoxynucleotide bearing Pd(II)-coproporphyrin I covalently linked to the 5'-end phosphate group.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 1990, Vol.259 (2), p.335-337
Hauptverfasser:	Fedorova, O.S., Savitskii, A.P., Shoikhet, K.G., Ponomarev, G.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Autoradiography Base Sequence Biological and medical sciences CMC, N-cyclohexyl-N'-morpholinoethyl carbodiimide metho-p-toluenesulfonate Coproporphyrins DMAP, 4-dimethylaminopyridine DMF, dimethylformamide DMSO, dimethylsulfoxide Fundamental and applied biological sciences. Psychology Molecular Sequence Data Nucleic acids Nucleic bases, nucleotides Oligodeoxyribonucleotides - chemical synthesis Palladium Pd(II)-coproporphyrin I Phosphorus Radioisotopes Photochemistry Photoirradiation Por (COOH)4, palladium (II)-coproporphyrin I Porphyrins Sequence-specific modification
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The 34-mer oligodeoxynucleotide was shown to be selectively modified at the G17 position upon photoirradiation in the presence of complementary 17-mer oligodeoxynucleotide bearing Pd(II)-coproporphyrin I covalently linked to the 5'-end phosphate group.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(90)80041-G