The Role of Chromatin in HIV-1 Transcriptional Regulation

Regulation of transcription is a key feature of the HIV-1 life cycle. In recent years, various sequence elements and transcription factors have been shown to participate in HIV-1 transcription control. New evidence, however, has shown that chromatin organization plays a key role in the establishment...

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Veröffentlicht in:	Immunobiology (1979) 1997-12, Vol.198 (1), p.279-290
1. Verfasser:	Mirkovitch, Jovan
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Chromatin Deoxyribonuclease I - metabolism DNA Footprinting Forecasting Gene Expression Regulation, Viral Gene Products, tat - metabolism HIV Long Terminal Repeat HIV-1 - genetics Humans Nucleosomes Peptide Chain Elongation, Translational Proteins - metabolism Regulatory Sequences, Nucleic Acid tat Gene Products, Human Immunodeficiency Virus Transcription Factors - metabolism Transcription, Genetic
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Beschreibung
Zusammenfassung:	Regulation of transcription is a key feature of the HIV-1 life cycle. In recent years, various sequence elements and transcription factors have been shown to participate in HIV-1 transcription control. New evidence, however, has shown that chromatin organization plays a key role in the establishment of a transcriptionally regulated HIV-1 LTR. The present review discusses recent data obtained on reconstituted and genomic HIV-1 chromatin templates.
ISSN:	0171-2985 1878-3279
DOI:	10.1016/S0171-2985(97)80048-4