Chronic Treatment with Propranolol Induces Antioxidant Changes and Protects Against Ischemia–Reperfusion Injury

The goal of this study was to examine whether chronic administration of propranolol offers protection against ischemia–reperfusion injury and whether it induces any change in the myocardial endogenous antioxidant enzyme activities and their gene expression. Rats were treated with propranolol (10 mg/...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 1997-12, Vol.29 (12), p.3335-3344
Hauptverfasser:	Khaper, Neelam, Rigatto, Claudio, Seneviratne, Charita, Li, Timao, Singal, Pawan K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - pharmacology Animals Antioxidants Antioxidants - metabolism Catalase - metabolism Glutathione Peroxidase - metabolism Hemodynamics - drug effects In Vitro Techniques Lipid peroxidation Lipid Peroxides - metabolism Male Myocardial Contraction - drug effects Myocardial Reperfusion Injury - prevention & control Myocardium - enzymology Myocardium - metabolism Propranolol - administration & dosage Propranolol - pharmacology Rats Rats, Sprague-Dawley Reperfusion recovery Superoxide Dismutase - metabolism β-blockade
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