Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures

The seizure-modulating effects of 2-chloroadenosine (2-CLA) infused directly into the amygdala were investigated. Different groups of amygdala-kindled rats were infused (1 μl) with 2-CLA (0.25, 1, 10 and 25 nM), caffeine (200 μM and 2 mM), a combination of the two or artificial cerebrospinal fluid (...

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Veröffentlicht in:Brain research 1997-11, Vol.775 (1-2), p.37-42
Hauptverfasser: Pourgholami, M.H, Rostampour, M, Mirnajafi-Zadeh, J, Palizvan, M.R
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Sprache:eng
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Zusammenfassung:The seizure-modulating effects of 2-chloroadenosine (2-CLA) infused directly into the amygdala were investigated. Different groups of amygdala-kindled rats were infused (1 μl) with 2-CLA (0.25, 1, 10 and 25 nM), caffeine (200 μM and 2 mM), a combination of the two or artificial cerebrospinal fluid (ACSF) applied directly through a cannula located in the amygdala. Infusion of 2-CLA dramatically suppressed seizure stage (SS), after discharge duration (ADD) and stage 5 seizure duration (S5D), while the latency to bilateral forelimb clonus (S4L) was significantly prolonged. These anticonvulsant effects were evident after 5 min, reached a maximum at the 60 min time point and were still detectable 360 min post-2-CLA infusion. Pretreatment with caffeine blocked the anticonvulsant effects of 2-CLA dose-dependently. These results may suggest that in amygdaloid-kindled rats, adenosine receptors located in the amygdala play a major role in the expression of the anticonvulsant activity of 2-CLA.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(97)00769-5