Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest

Bioassay-guided fractionation of the EtOAc extract of both Allamanda cathartica and Himatanthus fallax (Apocynaceae) using the Sc-7 yeast strain resulted in the isolation of the weakly cytotoxic isoplumericin and plumericin. In addition, the new lignan 7(R)-methoxy-8-epi-matairesional and three know...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1997-12, Vol.60 (12), p.1294-1297
Hauptverfasser:	Abdel-Kader, M.S, Wisse, J, Evans, R, Werff, H. van der, Kingston, D.G.I
Format:	Artikel
Sprache:	eng
Schlagworte:	7(R)-METHOXY-8-EPI-MATAIRESINOL ALLAMANDA Animals Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology APOCYNACEAE Biological and medical sciences CHEMICAL COMPOSITION CHEMICAL STRUCTURE CHEMISTRY CHIMIE COMPOSICION QUIMICA COMPOSITION CHIMIQUE CYTOTOXIC COMPOUNDS DRUG PLANTS Drug Screening Assays, Antitumor ESPECTROMETRIA ESTRUCTURA QUIMICA FEUILLE Furans - isolation & purification Furans - pharmacology General pharmacology HOJAS IRIDOIDE IRIDOIDES IRIDOIDS ISOPLUMERICIN LEAVES Lignans - isolation & purification Lignans - pharmacology Magnetic Resonance Spectroscopy Mass Spectrometry MATARESINOL Medical sciences Mice PHARMACEUTICAL PRODUCTS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments PINORESINOL PLANTAS MEDICINALES PLANTE MEDICINALE Plants, Medicinal - chemistry PLUMERICIN PLUMIERIDE QUIMICA Saccharomyces cerevisiae - drug effects SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY Spiro Compounds - isolation & purification Spiro Compounds - pharmacology STEMS STEREOCHEMISTRY STRUCTURE CHIMIQUE SUBSTANCE TOXIQUE SURINAME SUSTANCIAS TOXICAS TALLO TIGE TOXIC SUBSTANCES Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Bioassay-guided fractionation of the EtOAc extract of both Allamanda cathartica and Himatanthus fallax (Apocynaceae) using the Sc-7 yeast strain resulted in the isolation of the weakly cytotoxic isoplumericin and plumericin. In addition, the new lignan 7(R)-methoxy-8-epi-matairesional and three known compounds, plumieride, matairesinol, and pinoresinol, were isolated from H. fallax.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np970253e