Hemodynamic regulation of the dental pulp in a low compliance environment

Pulpal hemodynamic regulation has been investigated in experimental animals using 133Xe washout, 15-μm radioisotope-labeled microsphere injection, and intravital microscope methods. Three distinct types of pulp blood flow reductions were observed. Type I was characterized by reduction in response to...

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Veröffentlicht in:Journal of endodontics 1989-09, Vol.15 (9), p.404-408
Hauptverfasser: Kim, Syngcuk, Dörscher-Kim, Jutta
Format: Artikel
Sprache:eng
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Zusammenfassung:Pulpal hemodynamic regulation has been investigated in experimental animals using 133Xe washout, 15-μm radioisotope-labeled microsphere injection, and intravital microscope methods. Three distinct types of pulp blood flow reductions were observed. Type I was characterized by reduction in response to direct stimulation of the sympathetic nerve; intraarterial infusion of norepinephrine, 5-HT, or prostaglandin F 2α; and indirect stimulation of the sympathetic nerve. The Type II response, an initial increase in flow followed by a decrease, was observed with isoproterenol, prostaglandin E 2, substance P, and bradykinin. This biphasic flow response is caused by the low compliance environment of the tooth and may play a role in pulp inflammatory processes. The Type III response follows administration of histamine and is characterized by a gradual decrease in pulpal blood flow.
ISSN:0099-2399
1878-3554
DOI:10.1016/S0099-2399(89)80172-4