Systemic absorption of gentamicin ear drops

Aminoglycoside-containing topical preparations are commonly used in the treatment of chronic suppurative otitis media and otitis externa. We report a case where systemic absorption of topical Gentisone HC™ occurred producing a serum gentamicin level of 6.2 μg/ml.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of laryngology and otology 1997-10, Vol.111 (10), p.960-962
Hauptverfasser:	Green, K. M. J., Lappin, D. W. P., Curley, J. W. A., de Carpentier, J. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Administration, Topical Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Biological and medical sciences Clinical Records Drug toxicity and drugs side effects treatment Ear Gentamicin Gentamicins - blood Gentamicins - pharmacokinetics Gentamicins - therapeutic use Humans Kidney Failure, Chronic - blood Male Medical sciences Middle Aged Otitis Media, Suppurative - blood Otitis Media, Suppurative - drug therapy Pharmacology. Drug treatments toxicity Toxicity: blood
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Beschreibung
Zusammenfassung:	Aminoglycoside-containing topical preparations are commonly used in the treatment of chronic suppurative otitis media and otitis externa. We report a case where systemic absorption of topical Gentisone HC™ occurred producing a serum gentamicin level of 6.2 μg/ml.
ISSN:	0022-2151 1748-5460 1748-5640
DOI:	10.1017/S0022215100139076