Epstein‐Barr virus‐related Hodgkin's disease showing B cell lineage in an immunosuppressive patient seropositive for HTLV‐I

A case of Hodgkln's disease (HD), lymphocyte depression (LD) type In an Immunosuppressive patient is described. The patient was a 48‐year‐old male and his parents were born In the Kyushu area, which is an endemic area for adult T cell lymphomaheukemla (ATL). He was seropositive for ATL virus (ATLV, also referred to as HTLV‐I) and showed a marked Immunosuppressive condition. He developed LD‐HD and Pneumocystis carinii pneumonia, and died due to respiratory failure. The Immunohistochemical and in situ hybridization analyses revealed that the Reed‐Sternberglike cells In the lymph node biopsy sample were positive for Ber‐H2 (CD30), Leu‐M1 (CD15), L‐26 (CD20), Bcl‐2, p53 and EBER, the viral genome of Epstein‐Barr virus (EBV).