The Long-Term Efficacy of Ibopamine in Treating Patients with Severe Heart Failure: A Multicenter Investigation

This randomized, double-blind, placebo-controlled, multicenter trial compared the effects of treatment with ibopamine with those of placebo in patients with severe heart failure who still showed symptoms although they were receiving standard therapy with digitalis and diuretics. The results showed a significant and sustained improvement in exercise tolerance (+ 70% about in average), clinical condition, and NYHA functional class and a decrease in cardiothoracic ratio and left ventricular end-systolic wall stress in patients treated with ibopamine. digitalis, and diuretics (group 1) compared with patients treated with digitalis, diuretics, and placebo (group 2).