Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Flavonoids. III
Sixty-one flavanones, twenty-six isoflavones and eight other flavonoids, obtained from Sophora tomentosa, S. flavescens, Scutellaria baicalensis and other medicinal plants or synthesized, were tested for their inhibitory activity against adenosine 3', 5'-cyclic monophosphate (cAMP) phospho...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1989/05/25, Vol.37(5), pp.1392-1395 |
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| container_issue | 5 |
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| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 37 |
| creator | NIKAIDO, Tamotsu OHMOTO, Taichi KINOSHITA, Takeshi SANKAWA, Ushio MONACHE, Franco Delle BOTTA, Bruno TOMIMORI, Tsuyoshi MIYAICHI, Yukinori SHIRATAKI, Yoshiaki YOKOE, Ichiro KOMATSU, Manki |
| description | Sixty-one flavanones, twenty-six isoflavones and eight other flavonoids, obtained from Sophora tomentosa, S. flavescens, Scutellaria baicalensis and other medicinal plants or synthesized, were tested for their inhibitory activity against adenosine 3', 5'-cyclic monophosphate (cAMP) phosphodiesterase from beef heart. The structure-activity relationships were investigated. |
| doi_str_mv | 10.1248/cpb.37.1392 |
| format | Article |
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III</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Sixty-one flavanones, twenty-six isoflavones and eight other flavonoids, obtained from Sophora tomentosa, S. flavescens, Scutellaria baicalensis and other medicinal plants or synthesized, were tested for their inhibitory activity against adenosine 3', 5'-cyclic monophosphate (cAMP) phosphodiesterase from beef heart. The structure-activity relationships were investigated.</description><subject>3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>cAMP phosphodiesterase</subject><subject>Enzymes and enzyme inhibitors</subject><subject>flavanone</subject><subject>flavonoids</subject><subject>Flavonoids - pharmacology</subject><subject>Fundamental and applied biological sciences. 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| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1989/05/25, Vol.37(5), pp.1392-1395 |
| issn | 0009-2363 1347-5223 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors Analytical, structural and metabolic biochemistry Biological and medical sciences cAMP phosphodiesterase Enzymes and enzyme inhibitors flavanone flavonoids Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Hydrolases inhibitor isoflavone Structure-Activity Relationship |
| title | Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Flavonoids. III |
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