Relationship between lipophilicity and binding to human serum albumin of arylpropionic acid non-steroidal anti-inflammatory drugs

A possible relationship between lipophilicity and binding to human serum albumin was investigated for 11 arylpropionate non-steroidal anti-inflammatory drugs. The lipophilic parameter was determined by a reversed-phase high-performance liquid chromatographic procedure as the capacity factor ( k′). T...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1997-10, Vol.16 (2), p.223-229
Hauptverfasser:	Deschamps-Labat, Laurence, Péhourcq, Fabienne, Jagou, Maryline, Bannwarth, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - metabolism Arylpropionic acids Binding Sites Biological and medical sciences Chromatography, High Pressure Liquid - methods Dialysis General pharmacology Humans Lipophilicity Medical sciences Models, Chemical Non-steroidal anti-inflammatory drugs Pharmacology. Drug treatments Protein Binding Quantitative structure–activity relationship Serum Albumin - chemistry Serum Albumin - metabolism Structure-Activity Relationship
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