Relationship between lipophilicity and binding to human serum albumin of arylpropionic acid non-steroidal anti-inflammatory drugs
A possible relationship between lipophilicity and binding to human serum albumin was investigated for 11 arylpropionate non-steroidal anti-inflammatory drugs. The lipophilic parameter was determined by a reversed-phase high-performance liquid chromatographic procedure as the capacity factor ( k′). T...
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Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 1997-10, Vol.16 (2), p.223-229 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A possible relationship between lipophilicity and binding to human serum albumin was investigated for 11 arylpropionate non-steroidal anti-inflammatory drugs. The lipophilic parameter was determined by a reversed-phase high-performance liquid chromatographic procedure as the capacity factor (
k′). The binding of arylpropionic acids to human serum albumin was studied in vitro by equilibrium dialysis. For each compound, a Scatchard analysis was performed considering two classes of binding sites characterized by high- and low-affinity constants,
K
1 and
K
2, respectively. A linear relationship was found between lipophilicity and binding parameters,
n
1
K
1 (
r=0.88,
P |
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ISSN: | 0731-7085 1873-264X |
DOI: | 10.1016/S0731-7085(97)00017-4 |