ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane

We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione-xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is di...

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Veröffentlicht in:	Molecular and cellular biochemistry 1989-11, Vol.91 (1-2), p.131-136
Hauptverfasser:	Awasthi, Y C, Singh, S V, Ahmad, H, Wronski, L W, Srivastava, S K, LaBelle, E F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Adenosine Triphosphate - pharmacokinetics ATP Biological Transport, Active cell membranes Enzyme Activation - drug effects Erythrocyte Membrane - drug effects Erythrocyte Membrane - metabolism glutathione Glutathione - analogs & derivatives Glutathione - pharmacokinetics Humans Osmolar Concentration Temperature xenobiotics Xenobiotics - pharmacokinetics
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Beschreibung
Zusammenfassung:	We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione-xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is distinct from the system which actively transports oxidized glutathione from the erythrocytes.
ISSN:	0300-8177 1573-4919
DOI:	10.1007/BF00228088