ISOLATION AND CHARACTERIZATION OF AGGLOMERINS A, B, C AND D
New antibiotics, agglomerins A, B, C and D, were isolated from the culture broth of a bacterial strain identified as Enterobacter agglomerans. These antibiotics are acidic in nature and their sodium salts are obtained as colorless crystalline powders, soluble in lower alcohols. All the antibiotics s...
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| Veröffentlicht in: | Journal of antibiotics 1989/12/25, Vol.42(12), pp.1729-1733 |
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| container_end_page | 1733 |
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| container_issue | 12 |
| container_start_page | 1729 |
| container_title | Journal of antibiotics |
| container_volume | 42 |
| creator | SHOJI, JUN'ICHI SAKAZAKI, RYUJI HATTORI, TERUO MATSUMOTO, KOICHI UOTANI, NOBUO YOSHIDA, TADASHI |
| description | New antibiotics, agglomerins A, B, C and D, were isolated from the culture broth of a bacterial strain identified as Enterobacter agglomerans. These antibiotics are acidic in nature and their sodium salts are obtained as colorless crystalline powders, soluble in lower alcohols. All the antibiotics shows characteristic UV maxima at 248 and 298nm. Molecular formulas: A, C15H21O4Na; B, C17H23O4Na; C, C17H25O4Na and D, C19H27O4Na; were indicated by elemental analysis and MS. These antibiotics are active against a wide variety of anaerobic bacteria and weakly against aerobic Gram-positive bacteria in vitro. |
| doi_str_mv | 10.7164/antibiotics.42.1729 |
| format | Article |
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These antibiotics are acidic in nature and their sodium salts are obtained as colorless crystalline powders, soluble in lower alcohols. All the antibiotics shows characteristic UV maxima at 248 and 298nm. Molecular formulas: A, C15H21O4Na; B, C17H23O4Na; C, C17H25O4Na and D, C19H27O4Na; were indicated by elemental analysis and MS. These antibiotics are active against a wide variety of anaerobic bacteria and weakly against aerobic Gram-positive bacteria in vitro.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.42.1729</identifier><identifier>PMID: 2621155</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>4-Butyrolactone - analogs & derivatives ; agglomerin A ; agglomerin B ; agglomerin C ; agglomerin D ; anaerobic bacteria ; Anti-Bacterial Agents - analysis ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; antibiotics ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; Enterobacter - analysis ; Fermentation ; Gram-Negative Bacteria - drug effects ; gram-positive bacteria ; Gram-Positive Bacteria - drug effects ; Microbial Sensitivity Tests</subject><ispartof>The Journal of Antibiotics, 1989/12/25, Vol.42(12), pp.1729-1733</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2621155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHOJI, JUN'ICHI</creatorcontrib><creatorcontrib>SAKAZAKI, RYUJI</creatorcontrib><creatorcontrib>HATTORI, TERUO</creatorcontrib><creatorcontrib>MATSUMOTO, KOICHI</creatorcontrib><creatorcontrib>UOTANI, NOBUO</creatorcontrib><creatorcontrib>YOSHIDA, TADASHI</creatorcontrib><title>ISOLATION AND CHARACTERIZATION OF AGGLOMERINS A, B, C AND D</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>New antibiotics, agglomerins A, B, C and D, were isolated from the culture broth of a bacterial strain identified as Enterobacter agglomerans. These antibiotics are acidic in nature and their sodium salts are obtained as colorless crystalline powders, soluble in lower alcohols. All the antibiotics shows characteristic UV maxima at 248 and 298nm. Molecular formulas: A, C15H21O4Na; B, C17H23O4Na; C, C17H25O4Na and D, C19H27O4Na; were indicated by elemental analysis and MS. These antibiotics are active against a wide variety of anaerobic bacteria and weakly against aerobic Gram-positive bacteria in vitro.</description><subject>4-Butyrolactone - analogs & derivatives</subject><subject>agglomerin A</subject><subject>agglomerin B</subject><subject>agglomerin C</subject><subject>agglomerin D</subject><subject>anaerobic bacteria</subject><subject>Anti-Bacterial Agents - analysis</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antibiotics</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Enterobacter - analysis</subject><subject>Fermentation</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>gram-positive bacteria</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>Microbial Sensitivity Tests</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPg0AUhSdGU-vjFxgTVq5KnXtnYJi4QvoiQUjaunFDBpgqDX3I0IX_XrSkcefm3uScLzc35xByB3QowOWPatuUWblrytwMOQ5BoDwjffA8sIG78pz0KUWwPQ_pJbkyZk0pE0x4PdJDFwEcp0-ewkUS-cswiS0_HlnBzJ_7wXI8D9-OYjKx_Ok0Sl5aKV5Y_sB6HljBLzu6IRcrVRl92-1r8joZL4OZHSXTMPAje43IGpsXuRA0Z0KAwoJlkjIO6EiusSgYRSnc9mU3l4KqVcYRhAsqQ8dxmCqYcNk1eTje3de7z4M2TbopTa6rSm317mBSIblA4cl_QXA4ExJoC9534CHb6CLd1-VG1V9pF0vrx0d_bRr1rk--qtuwK53-SR6k66UcU8Bu_tRwAvMPVad6y74BqA15zA</recordid><startdate>198912</startdate><enddate>198912</enddate><creator>SHOJI, JUN'ICHI</creator><creator>SAKAZAKI, RYUJI</creator><creator>HATTORI, TERUO</creator><creator>MATSUMOTO, KOICHI</creator><creator>UOTANI, NOBUO</creator><creator>YOSHIDA, TADASHI</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>198912</creationdate><title>ISOLATION AND CHARACTERIZATION OF AGGLOMERINS A, B, C AND D</title><author>SHOJI, JUN'ICHI ; SAKAZAKI, RYUJI ; HATTORI, TERUO ; MATSUMOTO, KOICHI ; UOTANI, NOBUO ; YOSHIDA, TADASHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j223t-4dc770c3771a2d3b903412594e2dd3029768816c970afb421761ab25553ad3763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>4-Butyrolactone - analogs & derivatives</topic><topic>agglomerin A</topic><topic>agglomerin B</topic><topic>agglomerin C</topic><topic>agglomerin D</topic><topic>anaerobic bacteria</topic><topic>Anti-Bacterial Agents - analysis</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>antibiotics</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Enterobacter - analysis</topic><topic>Fermentation</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>gram-positive bacteria</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>Microbial Sensitivity Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHOJI, JUN'ICHI</creatorcontrib><creatorcontrib>SAKAZAKI, RYUJI</creatorcontrib><creatorcontrib>HATTORI, TERUO</creatorcontrib><creatorcontrib>MATSUMOTO, KOICHI</creatorcontrib><creatorcontrib>UOTANI, NOBUO</creatorcontrib><creatorcontrib>YOSHIDA, TADASHI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHOJI, JUN'ICHI</au><au>SAKAZAKI, RYUJI</au><au>HATTORI, TERUO</au><au>MATSUMOTO, KOICHI</au><au>UOTANI, NOBUO</au><au>YOSHIDA, TADASHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ISOLATION AND CHARACTERIZATION OF AGGLOMERINS A, B, C AND D</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1989-12</date><risdate>1989</risdate><volume>42</volume><issue>12</issue><spage>1729</spage><epage>1733</epage><pages>1729-1733</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>New antibiotics, agglomerins A, B, C and D, were isolated from the culture broth of a bacterial strain identified as Enterobacter agglomerans. These antibiotics are acidic in nature and their sodium salts are obtained as colorless crystalline powders, soluble in lower alcohols. All the antibiotics shows characteristic UV maxima at 248 and 298nm. Molecular formulas: A, C15H21O4Na; B, C17H23O4Na; C, C17H25O4Na and D, C19H27O4Na; were indicated by elemental analysis and MS. These antibiotics are active against a wide variety of anaerobic bacteria and weakly against aerobic Gram-positive bacteria in vitro.</abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>2621155</pmid><doi>10.7164/antibiotics.42.1729</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1989/12/25, Vol.42(12), pp.1729-1733 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79472789 |
| source | J-STAGE Free; MEDLINE |
| subjects | 4-Butyrolactone - analogs & derivatives agglomerin A agglomerin B agglomerin C agglomerin D anaerobic bacteria Anti-Bacterial Agents - analysis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology antibiotics Chemical Phenomena Chemistry Chromatography, High Pressure Liquid Enterobacter - analysis Fermentation Gram-Negative Bacteria - drug effects gram-positive bacteria Gram-Positive Bacteria - drug effects Microbial Sensitivity Tests |
| title | ISOLATION AND CHARACTERIZATION OF AGGLOMERINS A, B, C AND D |
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