ISOLATION AND CHARACTERIZATION OF AGGLOMERINS A, B, C AND D

New antibiotics, agglomerins A, B, C and D, were isolated from the culture broth of a bacterial strain identified as Enterobacter agglomerans. These antibiotics are acidic in nature and their sodium salts are obtained as colorless crystalline powders, soluble in lower alcohols. All the antibiotics s...

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Veröffentlicht in:	Journal of antibiotics 1989/12/25, Vol.42(12), pp.1729-1733
Hauptverfasser:	SHOJI, JUN'ICHI, SAKAZAKI, RYUJI, HATTORI, TERUO, MATSUMOTO, KOICHI, UOTANI, NOBUO, YOSHIDA, TADASHI
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives agglomerin A agglomerin B agglomerin C agglomerin D anaerobic bacteria Anti-Bacterial Agents - analysis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology antibiotics Chemical Phenomena Chemistry Chromatography, High Pressure Liquid Enterobacter - analysis Fermentation Gram-Negative Bacteria - drug effects gram-positive bacteria Gram-Positive Bacteria - drug effects Microbial Sensitivity Tests
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Zusammenfassung:	New antibiotics, agglomerins A, B, C and D, were isolated from the culture broth of a bacterial strain identified as Enterobacter agglomerans. These antibiotics are acidic in nature and their sodium salts are obtained as colorless crystalline powders, soluble in lower alcohols. All the antibiotics shows characteristic UV maxima at 248 and 298nm. Molecular formulas: A, C15H21O4Na; B, C17H23O4Na; C, C17H25O4Na and D, C19H27O4Na; were indicated by elemental analysis and MS. These antibiotics are active against a wide variety of anaerobic bacteria and weakly against aerobic Gram-positive bacteria in vitro.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.42.1729