Effects of xylamidine on peripheral 5-hydroxytryptamine-induced anorexia

Rats injected peripherally with 5-hydroxytryptamine (5-HT) showed a dose-dependent decrease in food intake following overnight fasting. The peripheral 5-HT-2 antagonist xylamidine had no effect on food intake when administered alone, but antagonised 5-HT-induced anorexia. However, at the highest dos...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1989-12, Vol.34 (4), p.717-720
Hauptverfasser:	Edwards, Stephen, Stevens, Robin G.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT receptors 5-Hydroxytryptamine Amidines - pharmacology Animals Anorexia Biological and medical sciences Feeding Behavior - drug effects Food intake Histamine and antagonists. Allergy Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Serotonin - pharmacology Serotonin Antagonists - pharmacology Xylamidine
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Zusammenfassung:	Rats injected peripherally with 5-hydroxytryptamine (5-HT) showed a dose-dependent decrease in food intake following overnight fasting. The peripheral 5-HT-2 antagonist xylamidine had no effect on food intake when administered alone, but antagonised 5-HT-induced anorexia. However, at the highest dose of 5-HT (5 mg/kg), both doses of xylamidine (1.0 and 2.0 mg/kg) displayed the same degree of antagonism to the anorectic effect, but failed to block it completely. The results are discussed in terms of 5-HT receptor subtypes, and it is suggested that non-5-HT-2 receptors may be partially responsible for the mediation of peripheral 5-HT-induced anorexia.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(89)90264-5