Prevention of peritoneal metastasis of cancer with dextran sulfate—an experimental study in mice

Peritoneal metastases occur most often in the greater omentum, where tumor implantation sites are densely distributed. We used dextran sulfate (S-Dex) as an anti-celladherence agent to prevent i.p. seeded malignant cells from causing peritoneal metastases. S-Dex was tested for its antiadherent activ...

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Veröffentlicht in:Anti-cancer drugs 1997-10, Vol.8 (9), p.894-897
Hauptverfasser: Hagiwara, Akeo, Sawai, Kiyoshi, Sakakura, Chouhei, Shirasu, Morio, Ohgaki, Masaharu, Imanishi, Tsutomu, Yamasaki, Junya, Togawa, Tsuyoshi, Takahashi, Toshio
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Sprache:eng
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Zusammenfassung:Peritoneal metastases occur most often in the greater omentum, where tumor implantation sites are densely distributed. We used dextran sulfate (S-Dex) as an anti-celladherence agent to prevent i.p. seeded malignant cells from causing peritoneal metastases. S-Dex was tested for its antiadherent activity against B-16 melanoma cells on plastic, and was examined for its ability to prevent implantation in the omentum and to improve survival in mice after B-16 melanoma was inoculated i.p. S-Dex prevented B-16 melanoma cells from adhering to the plastic wall. S-Dex reduced the number of B-16 melanoma cells implanted into the greater omentum and improved the survival of mice inoculated with B-16 melanoma cells. We conclude that SDex attenuated peritoneal metastases when B-16 melanoma cells were seeded i.p.
ISSN:0959-4973
1473-5741
DOI:10.1097/00001813-199710000-00011