Clotting factor IX levels in C/EBPα knockout mice

Previous studies have indicated that C/EBPα is involved in the regulation of factor IX and mutations of a C/EBP recognition element in the factor IX promoter result in haemophilia B. We now report that mice homozygous for the deletion of the c/ebpα gene are significantly deficient in factor IX trans...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of haematology 1997-12, Vol.99 (3), p.578-579
Hauptverfasser:	Davies, N., Austen, D. E. G., Wilde, M. D., Darlington, G. J., Brownlee, G. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Northern C/EBPα factor IX Factor IX - genetics Factor IX - metabolism haemophilia B Leyden Hematologic and hematopoietic diseases knockout mice Medical sciences Mice Mice, Knockout Mutation Platelet diseases and coagulopathies RNA, Messenger - metabolism Transcription, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Previous studies have indicated that C/EBPα is involved in the regulation of factor IX and mutations of a C/EBP recognition element in the factor IX promoter result in haemophilia B. We now report that mice homozygous for the deletion of the c/ebpα gene are significantly deficient in factor IX transcription.
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.1997.4603263.x