Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

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Veröffentlicht in:	Journal of medicinal chemistry 1997-11, Vol.40 (24), p.3865-3868
Hauptverfasser:	SELNICK, Harold G., LIVERTON, Nigel J., BALDWIN, John J., BUTCHER, John W., CLAREMON, David A., ELLIOTT, Jason M., FREIDINGER, Roger M., KING, Stella A., LIBBY, Brian E., MCINTYRE, Charles J., PRIBUSH, David A., REMY, David C., SMITH, Garry R., TEBBEN, Andrew J., JURKIEWICZ, Nancy K., LYNCH, Joseph J., SALATA, Joseph J., SANGUINETTI, Michael C., SIEGL, Peter K. S., SLAUGHTER, Donald E., VYAS, Kamlesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - chemical synthesis Acetamides - pharmacology Administration, Oral Animals Anti-Arrhythmia Agents - chemical synthesis Anti-Arrhythmia Agents - pharmacology Antiarythmic agents Benzodiazepinones - chemical synthesis Benzodiazepinones - pharmacology Biological and medical sciences Cardiovascular system Cells, Cultured Dogs Electrocardiography, Ambulatory - drug effects Guinea Pigs Heart - drug effects Heart - physiology Humans Medical sciences Myocardium - cytology Pharmacology. Drug treatments Potassium Channel Blockers Potassium Channels - physiology Xenopus
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