Studies on the effect of an alkaloid extract of Symphytum officinale on human lymphocyte cultures

An alkaloid extract of Symphytum officinale was investigated for its chromosome-damaging effect in human lymphocytes in vitro. In concentrations of 1.4 micrograms/ml and 14 micrograms/ml the alkaloids had no effect, in concentrations of 140 micrograms/ml and 1400 micrograms/ml the alkaloids induced...

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Veröffentlicht in:	Planta medica 1989-12, Vol.55 (6), p.518-522
Hauptverfasser:	Behninger, C, Abel, G, Röder, E, Neuberger, V, Göggelmann, W
Format:	Artikel
Sprache:	ger
Schlagworte:	Alkaloids - isolation & purification Alkaloids - pharmacology Animals Chromosomes - drug effects Humans Liver - enzymology Lymphocytes - drug effects Lymphocytes - ultrastructure Molecular Structure Plants, Medicinal - analysis Rats Sister Chromatid Exchange - drug effects
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Zusammenfassung:	An alkaloid extract of Symphytum officinale was investigated for its chromosome-damaging effect in human lymphocytes in vitro. In concentrations of 1.4 micrograms/ml and 14 micrograms/ml the alkaloids had no effect, in concentrations of 140 micrograms/ml and 1400 micrograms/ml the alkaloids induced sister chromatid exchanges (SCE) as well as chromosome aberrations. Additionally, the influence of rat liver enzymes (S9) was tested. The SCE-inducing capacity and the clastogenic effect of Symphytum alkaloids was increased by simultaneous application of S9-Mix.
ISSN:	0032-0943
DOI:	10.1055/s-2006-962084