Anti-inflammatory evaluation of a hydroalcoholic extract of black currant leaves (Ribes nigrum)

A hydroalcoholic extract of black currant (Ribes nigrum) leaves was tested on carrageenan-induced rat paw oedema. Pharmacological activity was compared with indomethacin and niflumic acid using acute and chronic (21 or 28 days) oral treatment. Black currant extract and lyophilisate revealed signific...

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Veröffentlicht in:	Journal of ethnopharmacology 1989-11, Vol.27 (1/2), p.91-98
1. Verfasser:	Declume, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal Biological and medical sciences Carrageenan Cognitive problems, arts and sciences, folk traditions, folklore Edema - chemically induced Edema - drug therapy Ethnobotanics. Ethnoecology Ethnology Female France Gastric Mucosa - drug effects General pharmacology Indomethacin - pharmacology leaves Male Medical sciences Niflumic Acid - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - adverse effects Plant Extracts - pharmacology Plants, Medicinal - analysis Rats Rats, Inbred Strains Ribes nigrum Traditional sciences and medicine
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Zusammenfassung:	A hydroalcoholic extract of black currant (Ribes nigrum) leaves was tested on carrageenan-induced rat paw oedema. Pharmacological activity was compared with indomethacin and niflumic acid using acute and chronic (21 or 28 days) oral treatment. Black currant extract and lyophilisate revealed significant anti-inflammatory activity comparable to that seen with the reference substances, but without their ulcerogenic potential, even at high doses during chronic treatment.
ISSN:	0378-8741 1872-7573
DOI:	10.1016/0378-8741(89)90081-0