Recombination initiation: easy as A, B, C, D... chi?

The octameric Chi (chi) sequence is a recombination hotspot in Escherichia coli. Recent studies suggest a singular mechanism by which chi regulates not only the nuclease activity of RecBCD enzyme, but also the ability of RecBCD to promote loading of the strand exchange protein, RecA, onto chi-contai...

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Veröffentlicht in:	Current biology 1997-12, Vol.7 (12), p.R745-R749
Hauptverfasser:	Eggleston, A K, West, S C
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites DNA, Bacterial - genetics Escherichia coli - genetics Exodeoxyribonuclease V Exodeoxyribonucleases - metabolism Mutation Rec A Recombinases - metabolism Recombination, Genetic
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The octameric Chi (chi) sequence is a recombination hotspot in Escherichia coli. Recent studies suggest a singular mechanism by which chi regulates not only the nuclease activity of RecBCD enzyme, but also the ability of RecBCD to promote loading of the strand exchange protein, RecA, onto chi-containing DNA.
ISSN:	0960-9822
DOI:	10.1016/S0960-9822(06)00394-0