Glycosaminoglycans and WNTs: just a spoonful of sugar helps the signal go down

New studies have brought Drosophila geneticists face to face with some perplexing questions about proteoglycans and their role in growth factor signaling. Three papers published in Development report that mutations in the gene encoding UDP-glucose dehydrogenase disrupt both the synthesis of glycosam...

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Veröffentlicht in:	Trends in genetics 1997-11, Vol.13 (11), p.421-423
Hauptverfasser:	Cumberledge, Susan, Reichsman, Frieda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Classical genetics, quantitative genetics, hybrids Drosophila - genetics Drosophila - physiology Drosophila Proteins Fundamental and applied biological sciences. Psychology Genes, Insect Genetics of eukaryotes. Biological and molecular evolution Glycosaminoglycans - chemistry Glycosaminoglycans - physiology Growth Substances - physiology Invertebrata Models, Biological Models, Molecular Proteoglycans - physiology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Signal Transduction - physiology Wnt Proteins Wnt1 Protein Zebrafish Proteins
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Beschreibung
Zusammenfassung:	New studies have brought Drosophila geneticists face to face with some perplexing questions about proteoglycans and their role in growth factor signaling. Three papers published in Development report that mutations in the gene encoding UDP-glucose dehydrogenase disrupt both the synthesis of glycosaminoglycans and WINGLESS/WNT signaling, while a fourth paper provides evidence that TGF- beta /DPP signaling is regulated by the proteoglycan DALLY.
ISSN:	0168-9525
DOI:	10.1016/S0168-9525(97)01275-4